Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Chem Commun (Camb). 2020 Sep 22;56(75):11058-11061. doi: 10.1039/d0cc05026a.
We report the efficient and selective Cu(ii)-catalysed β-silylation of naturally occurring dehydroalanine (Dha) residues in various ribosomally synthesized and post-translationally modified peptides (RiPPs). The method is also applicable to proteins, as was shown by the modification of a Dha residue that was chemically introduced into Small Ubiquitin-like Modifier (SUMO).
我们报告了在各种核糖体合成和翻译后修饰的肽（RiPPs）中有效且选择性的 Cu(ii)-催化β-硅烷基化天然存在的脱氢丙氨酸（Dha）残基。该方法也适用于蛋白质，这可以通过化学引入到小泛素样修饰物（SUMO）中的 Dha 残基的修饰来证明。
