Institute of Molecular Biology, Medical University of Innsbruck, A6020 Innsbruck, Austria.
Biochem J. 2020 Aug 28;477(16):2967-2970. doi: 10.1042/BCJ20200286.
Aspergillus fumigatus is the most common cause of invasive aspergillosis, a life-threatening infection mainly affecting immunocompromised patients. The essential metals copper and iron play crucial roles in virulence of this mold. Recently, the copper-regulatory transcription factor Mac1 was reported to additionally be involved in the control of iron acquisition. However, in the current study, neither growth assays on solid and in liquid media, analysis of siderophore production nor expression analysis of genes involved in iron acquisition indicated the involvement of Mac1 in the regulation of iron uptake in A. fumigatus.
烟曲霉是侵袭性曲霉病的最常见原因，这是一种危及生命的感染，主要影响免疫功能低下的患者。必需金属铜和铁在这种霉菌的毒力中起着至关重要的作用。最近，报道铜调节转录因子 Mac1 还参与铁摄取的控制。然而，在本研究中，无论是在固体和液体培养基上的生长测定、分析铁载体的产生，还是参与铁摄取的基因的表达分析，都没有表明 Mac1 参与了烟曲霉中铁摄取的调节。
