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Mitochondrial glycerol 3-phosphate dehydrogenase deficiency aggravates hepatic triglyceride accumulation and steatosis.

作者信息

Dalamaga Maria, Liu Junli

机构信息

School of Medicine, Attikon General University Hospital, National and Kapodistrian University of Athens, Greece.

Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University Affiliated 6th People`s Hospital, Shanghai Diabetes Institute, Shanghai, China.

出版信息

Metabol Open. 2019 Mar 8;3:100004. doi: 10.1016/j.metop.2019.02.002. eCollection 2019 Sep.

DOI:10.1016/j.metop.2019.02.002
PMID:32812935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7424802/
Abstract
摘要

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Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Contributes to Hepatic Steatosis.线粒体甘油 3-磷酸脱氢酶缺乏导致肝脂肪变性。
Hepatology. 2019 Jul;70(1):84-97. doi: 10.1002/hep.30507. Epub 2019 Mar 15.
2
Cyclophilin D deficiency attenuates mitochondrial perturbation and ameliorates hepatic steatosis.环孢素 D 缺乏可减轻线粒体扰动并改善肝脂肪变性。
Hepatology. 2018 Jul;68(1):62-77. doi: 10.1002/hep.29788. Epub 2018 May 9.
3
Nonalcoholic steatohepatitis (NASH) drugs market.非酒精性脂肪性肝炎（NASH）药物市场。
DRAK2-SRSF6调控的RNA可变剪接是NAFLD/NASH中一个有前景的治疗靶点。
Metabol Open. 2021 Dec 8;13:100157. doi: 10.1016/j.metop.2021.100157. eCollection 2022 Mar.
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Emerging roles for stress kinase p38 and stress hormone fibroblast growth factor 21 in NAFLD development.应激激酶p38和应激激素成纤维细胞生长因子21在非酒精性脂肪性肝病发展中的新作用。
Metabol Open. 2021 Nov 30;12:100153. doi: 10.1016/j.metop.2021.100153. eCollection 2021 Dec.
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PIN1, a perspective on genetic biomarker for nonalcoholic fatty liver disease (NAFLD).PIN1，非酒精性脂肪性肝病（NAFLD）遗传生物标志物的研究视角。
Metabol Open. 2019 Aug 6;3:100014. doi: 10.1016/j.metop.2019.100014. eCollection 2019 Sep.
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Protein misfolding in the endoplasmic reticulum as a conduit to human disease.内质网中蛋白质的错误折叠作为通向人类疾病的途径。
Nature. 2016 Jan 21;529(7586):326-35. doi: 10.1038/nature17041.
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Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.二甲双胍通过抑制线粒体甘油磷酸脱氢酶抑制糖异生。
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