Wang Jing-Zhang, Zhang Yu-Hua, Bai Jing, Liu Yan-Wei, Du Wen-Tao
Affiliated Hospital, College of Medicine, College of Life Sciences and Food Engineering, Hebei University of Engineering, Handan, 056038, PR China.
Metabol Open. 2019 Aug 6;3:100014. doi: 10.1016/j.metop.2019.100014. eCollection 2019 Sep.
A novel genetic and molecular basis of nonalcoholic fatty liver disease (NAFLD) was explored.
A 38-year-old male, who has no bad living and dietary habits, was diagnosed as NAFLD. The potential pathogenic role of Pin1 was evaluated by enzyme-linked immunosorbent (ELISA) assay and single nucleotide polymorphism (SNP) sequencing.
ELISA determined a six-time higher concentration of plasma Pin1 compared to our previous data. Nine SNPs were sequenced and classified according to their NAFLD-pathogenic risks, suggesting that rs2233678 and rs2287839 may be the most important genotypes that result in Pin1 overexpression and NAFLD development.
In summary, this work explores a novel basis for early-onset NAFLD and highlights that elevated plasma Pin1 may predict NAFLD risk at early stage. Hypothetically, inhibiting Pin1 may benefit NAFLD prevention in the future.
探索非酒精性脂肪性肝病（NAFLD）新的遗传和分子基础。
一名38岁男性，无不良生活和饮食习惯，被诊断为NAFLD。通过酶联免疫吸附测定（ELISA）和单核苷酸多态性（SNP）测序评估Pin1的潜在致病作用。
ELISA测定显示，与我们之前的数据相比，血浆Pin1浓度高出六倍。对9个SNP进行测序，并根据其NAFLD致病风险进行分类，表明rs2233678和rs2287839可能是导致Pin1过表达和NAFLD发展的最重要基因型。
总之，本研究探索了早发性NAFLD的新基础，并强调血浆Pin1升高可能在早期预测NAFLD风险。假设，抑制Pin1可能在未来对NAFLD预防有益。
