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异常的静息态脑网络组织与听觉言语幻觉。

Abnormal dynamic resting-state brain network organization in auditory verbal hallucination.

机构信息

Center for Brain Disorders and Cognitive Sciences, Shenzhen University, Shenzhen, China.

Department of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

出版信息

Brain Struct Funct. 2020 Nov;225(8):2315-2330. doi: 10.1007/s00429-020-02119-1. Epub 2020 Aug 19.

Abstract

Auditory-verbal hallucinations (AVH) are a key symptom of schizophrenia. Recent neuroimaging studies examining dynamic functional connectivity suggest that disrupted dynamic interactions between brain networks characterize complex symptoms in mental illness including schizophrenia. Studying dynamic connectivity may be especially relevant for hallucinations, given their fluctuating phenomenology. Indeed, it remains unknown whether AVH in schizophrenia are directly related to altered dynamic connectivity within and between key brain networks involved in auditory perception and language, emotion processing, and top-down control. In this study, we used dynamic connectivity approaches including sliding window and k-means to examine dynamic interactions among brain networks in schizophrenia patients with and without a recent history of AVH. Dynamic brain network analysis revealed that patients with AVH spent less time in a 'network-antagonistic' brain state where the default mode network (DMN) and the language network were anti-correlated, and had lower probability to switch into this brain state. Moreover, patients with AVH showed a lower connectivity within the language network and the auditory network, and lower connectivity was observed between the executive control and the language networks in certain dynamic states. Our study provides the first neuroimaging evidence of altered dynamic brain networks for understanding neural mechanisms of AVH in schizophrenia. The findings may inform and further strengthen cognitive models of AVH that aid the development of new coping strategies for patients.

摘要

听觉言语幻觉(AVH)是精神分裂症的一个关键症状。最近研究动态功能连接的神经影像学研究表明,大脑网络之间的动态相互作用中断是包括精神分裂症在内的精神疾病的复杂症状的特征。研究动态连接性对于幻觉可能特别重要,因为它们的现象学是波动的。事实上,目前还不清楚精神分裂症中的 AVH 是否与听觉感知和语言、情感处理以及自上而下控制中涉及的关键大脑网络内和网络之间的改变的动态连接直接相关。在这项研究中,我们使用了动态连接方法,包括滑动窗口和 k-means,来检查有和没有近期 AVH 病史的精神分裂症患者大脑网络之间的动态相互作用。动态脑网络分析显示,有 AVH 的患者在默认模式网络(DMN)和语言网络呈反相关的“网络拮抗”脑状态下花费的时间较少,并且进入这种脑状态的可能性较低。此外,有 AVH 的患者在语言网络和听觉网络内的连接性较低,在某些动态状态下,执行控制和语言网络之间的连接性也较低。我们的研究提供了关于精神分裂症中 AVH 的改变的动态脑网络的第一个神经影像学证据,为理解 AVH 的神经机制提供了信息,并进一步加强了对 AVH 的认知模型,为患者提供了新的应对策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5497/7544708/ecc9d24c1525/429_2020_2119_Fig1_HTML.jpg

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