Yale University School of Medicine and the Connecticut Mental Health Center, New Haven, CT, USA.
Columbia University Department of Neuroscience, New York, NY, USA.
Adv Neurobiol. 2024;40:665-681. doi: 10.1007/978-3-031-69491-2_22.
Auditory-verbal hallucinations (AVH) are debilitating symptoms experienced by those diagnosed with psychosis as well as many other neurological and psychiatric disorders. Critical to supporting individuals with AVH is identifying biomarkers that serve to track changes in brain states that put individuals at risk for developing or worsening of symptoms. There has been substantial literature identifying neural areas to track over time that may prove to be effective clinical tools. The efficacy of these tools has been bolstered when considering them under mechanistic accounts of AVH. In this chapter, we explore the literature that connects mechanistic theories and structurally based models of AVH and the potential biomarkers derived from this research.
听觉幻觉 (AVH) 是被诊断患有精神病以及许多其他神经和精神疾病的人的致残症状。支持有听觉幻觉的人的关键是确定生物标志物,以跟踪可能使个体处于出现或加重症状风险的大脑状态变化。有大量文献确定了随时间跟踪的神经区域,这些区域可能成为有效的临床工具。当从听觉幻觉的机制解释来考虑这些工具时,它们的功效得到了增强。在本章中,我们探讨了将听觉幻觉的机制理论和基于结构的模型联系起来的文献,以及由此研究得出的潜在生物标志物。