Omranipour Ramesh, Alipour Sadaf, Ensani Fereshteh, Nakhlis Faina
Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran.
Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
Adv Exp Med Biol. 2020;1252:63-72. doi: 10.1007/978-3-030-41596-9_8.
Papillomas, atypical hyperplasias, and lobular carcinoma in situ of the breast are not malignant tumors, but present serious management challenges when they are diagnosed in a breast biopsy . Upgrading after excision and increased possibility of future cancer are risks that accompany these lesions. While some features have been defined as high-risk for upgrading, many practitioners now recommend conservative non-surgical treatment and vacuum-assisted biopsy . However, the challenge gets worse when the patient is pregnant or breastfeeding because of the limitations in imaging and treatment in relation to the fetus. This chapter deals with these problems, although the best management strategy cannot be defined because of lack of evidence at present.
乳腺乳头状瘤、非典型增生及小叶原位癌并非恶性肿瘤，但在乳腺活检中被诊断出来时会带来严重的处理难题。切除后病变升级以及未来患癌可能性增加是这些病变所伴随的风险。虽然一些特征已被定义为病变升级的高危因素，但现在许多从业者建议采用保守的非手术治疗及真空辅助活检。然而，当患者怀孕或哺乳时，由于与胎儿相关的成像和治疗限制，问题会变得更加棘手。本章将探讨这些问题，尽管目前由于缺乏证据，尚无法确定最佳的处理策略。
