Department of Psychology, Virginia Commonwealth University.
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University.
Psychol Sci. 2020 Sep;31(9):1140-1149. doi: 10.1177/0956797620931542. Epub 2020 Aug 20.
Investigations of social-genetic effects, whereby a social partner's genotype affects another's outcomes, can be confounded by the influence of the social partner's rearing environment. We used marital information on more than 300,000 couples from Swedish national data to disentangle social-genetic from rearing-environment effects for alcohol use disorder (AUD). Using observational and extended-family designs, we found that (a) marriage to a spouse with a predisposition toward AUD (as indexed by a parental history of AUD) increased risk for developing AUD; (b) this increased risk was not explained by socioeconomic status, the spouse's AUD status, or contact with the spouse's parents; and (c) this increased risk reflected the psychological consequences of the spouse having grown up with an AUD-affected parent (i.e., a rearing-environment effect) rather than a social-genetic effect. Findings illustrate that a spouse's rearing-environment exposures may confer risk for AUD.
我们利用瑞典全国数据中超过 30 万对夫妇的婚姻信息，来厘清社交遗传与养育环境对酒精使用障碍（AUD）的影响。通过观察性和大家庭设计，我们发现：（a）与有 AUD 倾向的配偶（以 AUD 家族史为指标）结婚会增加 AUD 的发病风险；（b）这种风险增加不能用社会经济地位、配偶的 AUD 状况或与配偶父母的接触来解释；（c）这种风险增加反映了配偶在有 AUD 父母养育下成长的心理后果（即养育环境效应），而不是社交遗传效应。研究结果表明，配偶的养育环境暴露可能会使 AUD 发病风险增加。
