Department of Health Science, University of Piemonte Orientale , Novara, Italy.
Center for Translational Research on Autoimmune and Allergic Disease (CAAD), University of Piemonte Orientale , Novara, Italy.
Cell Cycle. 2020 Oct;19(19):2411-2425. doi: 10.1080/15384101.2020.1806426. Epub 2020 Aug 20.
Human skin melanoma is one of the most aggressive and difficult to treat human malignancies, with an increasing incidence over the years. While the resection of the early diagnosed primary tumor remains the best clinical approach, advanced/metastatic melanoma still remains with a poor prognosis. Indeed, although enormous progress in the therapeutic treatment of human tumors has been made in recent years, patients affected by metastatic melanoma are still poorly affected by these clinical advances. Therefore, new valuable therapeutic approaches are urgently needed, to design and define effective treatments to consistently increase the overall survival rate of patients affected by this malignancy. In this review we summarize the main signaling pathways studied to kill human skin melanoma, and introduce the ferroptotic cell death as a new pathway to be explored to eradicate this tumor.
人类皮肤黑色素瘤是最具侵袭性和最难治疗的人类恶性肿瘤之一，近年来发病率不断上升。虽然早期诊断的原发性肿瘤切除术仍然是最好的临床方法，但晚期/转移性黑色素瘤的预后仍然很差。事实上，尽管近年来在人类肿瘤的治疗方面取得了巨大进展，但转移性黑色素瘤患者仍然受到这些临床进展的不利影响。因此，迫切需要新的有价值的治疗方法，以设计和确定有效的治疗方法，持续提高受这种恶性肿瘤影响的患者的总生存率。在这篇综述中，我们总结了研究用于杀死人类皮肤黑色素瘤的主要信号通路，并介绍了铁死亡作为一种新的途径来探索消灭这种肿瘤。
