Zhu Jiahao, Shen Peipei, Xu Yu, Zhang Xiaojun, Chen Qingqing, Gu Ke, Ji Shengjun, Yang Bo, Zhao Yutian
Department of Radiotherapy and Oncology, The Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
Wuxi Clinical Cancer Center, Wuxi, Jiangsu, China.
Front Pharmacol. 2024 Jan 16;15:1290120. doi: 10.3389/fphar.2024.1290120. eCollection 2024.
Ferroptosis, distinct from apoptosis, is a novel cellular death pathway characterized by the build-up of lipid peroxidation and reactive oxygen species (ROS) derived from lipids within cells. Recent studies demonstrated the efficacy of ferroptosis inducers in targeting malignant cells, thereby establishing a promising avenue for combating cancer. Traditional Chinese medicine (TCM) has a long history of use and is widely used in cancer treatment. TCM takes a holistic approach, viewing the patient as a system and utilizing herbal formulas to address complex diseases such as cancer. Recent TCM studies have elucidated the molecular mechanisms underlying ferroptosis induction during cancer treatment. These studies have identified numerous plant metabolites and derivatives that target multiple pathways and molecular targets. TCM can induce ferroptosis in tumor cells through various regulatory mechanisms, such as amino acid, iron, and lipid metabolism pathways, which may provide novel therapeutic strategies for apoptosis-resistant cancer treatment. TCM also influence anticancer immunotherapy via ferroptosis. This review comprehensively elucidates the molecular mechanisms underlying ferroptosis, highlights the pivotal regulatory genes involved in orchestrating this process, evaluates the advancements made in TCM research pertaining to ferroptosis, and provides theoretical insights into the induction of ferroptosis in tumors using botanical drugs.
铁死亡不同于细胞凋亡，是一种新的细胞死亡途径，其特征是细胞内脂质过氧化和源自脂质的活性氧（ROS）积累。最近的研究证明了铁死亡诱导剂在靶向恶性细胞方面的有效性，从而为对抗癌症开辟了一条有前景的途径。中药有着悠久的使用历史，广泛应用于癌症治疗。中药采用整体方法，将患者视为一个系统，并利用草药配方来治疗癌症等复杂疾病。最近的中药研究阐明了癌症治疗期间诱导铁死亡的分子机制。这些研究已经确定了许多靶向多种途径和分子靶点的植物代谢物和衍生物。中药可以通过各种调节机制诱导肿瘤细胞发生铁死亡，如氨基酸、铁和脂质代谢途径，这可能为抗凋亡癌症治疗提供新的治疗策略。中药还通过铁死亡影响抗癌免疫疗法。本综述全面阐明了铁死亡的分子机制，强调了参与协调这一过程的关键调控基因，评估了中药在铁死亡研究方面取得的进展，并为使用植物药诱导肿瘤铁死亡提供了理论见解。
