通过原位杂交将人类癌基因INT1定位于12q13的染色体定位研究。
Chromosome localization of the human oncogene INT1 to 12q13 by in situ hybridization.
作者信息
Arheden K, Mandahl N, Strömbeck B, Isaksson M, Mitelman F
机构信息
Department of Clinical Genetics, University Hospital, Lund, Sweden.
出版信息
Cytogenet Cell Genet. 1988;47(1-2):86-7. doi: 10.1159/000132513.
The human oncogene INT1 has been mapped to chromosome band 12q13 by in situ hybridization. The precise localization of this gene is of particular interest, since the region 12q13----q14 has been reported to be involved in chromosomal rearrangements in lipomas, myxoid liposarcomas, pleomorphic adenomas, and myomas. The involvement of this region in both benign and malignant tumors suggests a common pathogenetic pathway in which changes affecting INT1 may be an important step.
通过原位杂交技术，已将人类癌基因INT1定位于染色体12q13带。该基因的确切定位尤为引人关注，因为据报道12q13----q14区域参与了脂肪瘤、黏液样脂肪肉瘤、多形性腺瘤和肌瘤的染色体重排。该区域在良性和恶性肿瘤中的参与表明存在一条共同的致病途径，其中影响INT1的变化可能是一个重要步骤。
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