原位杂交将人类假定癌基因GLI定位于染色体亚带12q13.3 - 14.1。
In situ hybridization localizes the human putative oncogene GLI to chromosome subbands 12q13.3-14.1.
作者信息
Arheden K, Rønne M, Mandahl N, Heim S, Kinzler K W, Vogelstein B, Mitelman F
机构信息
Department of Clinical Genetics, University Hospital, Lund, Sweden.
出版信息
Hum Genet. 1989 Apr;82(1):1-2. doi: 10.1007/BF00288260.
PMID:2497059
Abstract
Using in situ hybridization, we have localized the human putative oncogene GLI to chromosome subbands 12q13.3-14.1. The precise genomic site is of interest since the region 12q13-15 has been found to be consistently rearranged in neoplasia-associated chromosome abnormalities in lipomas, myxoid liposarcomas, uterine leiomyomas, and pleomorphic adenomas of the salivary gland.
摘要
利用原位杂交技术，我们已将人类假定癌基因GLI定位到染色体亚带12q13.3 - 14.1。该精确的基因组位点备受关注，因为在脂肪瘤、黏液样脂肪肉瘤、子宫平滑肌瘤和涎腺多形性腺瘤中，已发现12q13 - 15区域在肿瘤相关染色体异常中持续发生重排。
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