Stroke Branch, Neuroscience Division, Interdisciplinary Laboratory of Medicinal Investigation, School of Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
BRAINS Lab, Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, United States.
Curr Neurovasc Res. 2020;17(4):495-501. doi: 10.2174/1567202617999200819155636.
Stroke is a major cause of death and disability worldwide. Among its complications, post-stroke depression (PSD) leads to a significant burden. The diagnosis of PSD is complex, and there are no biomarkers that can assist in its early identification and adequate management.
The aim of the present study is to investigate peripheral biomarkers in the acute phase of stroke and their potential association with depressive symptoms.
We evaluated 60 patients in the acute phase of stroke by using standardized instruments of psychiatric and neurological assessment (Mini International Neuropsychiatric Interview-Plus- MINI-Plus, Hospital Anxiety and Depression Scale-HADS, and National Institutes of Health Stroke Scale-NIHSS) and measured peripheral biomarkers.
In multivariate analysis, low peripheral levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and higher NIHSS scores were associated with PSD. The severity of depressive symptoms was inversely correlated with sTREM-1 and glial cell-derived neurotrophic factor (GDNF) levels.
This is the first study indicating an association between sTREM-1 and PSD. Our results may point to the involvement of glial mechanisms in the manifestation of depressive symptoms after stroke.
卒中是全球范围内主要的死亡和残疾原因。其并发症中，卒中后抑郁（PSD）导致了巨大的负担。PSD 的诊断较为复杂，目前尚无生物标志物可用于其早期识别和充分管理。
本研究旨在探讨卒中急性期的外周生物标志物及其与抑郁症状的潜在关联。
我们使用精神病学和神经病学评估的标准化工具（MINI-Plus 复合版、医院焦虑和抑郁量表、NIHSS）评估了 60 例卒中急性期患者，并测量了外周生物标志物。
在多变量分析中，sTREM-1 外周水平低和 NIHSS 评分高与 PSD 相关。抑郁症状的严重程度与 sTREM-1 和胶质细胞源性神经营养因子（GDNF）水平呈负相关。
这是首个表明 sTREM-1 与 PSD 相关的研究。我们的结果可能表明，胶质细胞机制参与了卒中后抑郁症状的表现。
