髓系细胞触发受体-1（TREM-1）在中枢神经系统疾病中的作用。
The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases.
机构信息
Department of Neurology, The Third People's Hospital of Zhangjiagang City, Suzhou, 215600, Jiangsu, China.
Department of Neurobiology and Anatomy, XuzhouKeyLaboratoryofNeurobiology, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
出版信息
Mol Brain. 2022 Oct 22;15(1):84. doi: 10.1186/s13041-022-00969-w.
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily and is mainly expressed on the surface of myeloid cells such as monocytes, macrophages, and neutrophils. It plays an important role in the triggering and amplification of inflammatory responses, and it is involved in the development of various infectious and non-infectious diseases, autoimmune diseases, and cancers. In recent years, TREM-1 has also been found to participate in the pathological processes of several central nervous system (CNS) diseases. Targeting TREM-1 may be a promising strategy for treating these diseases. This paper aims to characterize TREM-1 in terms of its structure, signaling pathway, expression, regulation, ligands and pathophysiological role in CNS diseases.
触发受体表达于髓系细胞-1（TREM-1）是免疫球蛋白超家族的一员，主要表达于单核细胞、巨噬细胞和中性粒细胞等髓系细胞表面。它在炎症反应的触发和放大中发挥重要作用，参与多种感染性和非感染性疾病、自身免疫性疾病和癌症的发生发展。近年来，TREM-1 也被发现参与了几种中枢神经系统（CNS）疾病的病理过程。靶向 TREM-1 可能是治疗这些疾病的一种有前途的策略。本文旨在从结构、信号通路、表达、调节、配体以及在 CNS 疾病中的病理生理作用等方面对 TREM-1 进行综述。
Zotero 插件