Cancer Institute of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Department of Emergency, Qingdao Municipal Hospital, Shandong, 266011, China.
Biochem Biophys Res Commun. 2020 Sep 3;529(4):950-956. doi: 10.1016/j.bbrc.2020.06.033. Epub 2020 Jul 30.
β-arrestin-2, a multifunctional adaptor protein, was originally identified as a negative regulator of G protein-mediated signaling. We previously revealed that SUMOylation as a novel mechanism modulates β-arrestin-2-mediated IL-1R/TRAF6 signaling. However, the potential role of β-arrestin-2 SUMOylation in tumor cells was incompletely explored. In this study, we showed that SUMOylation deficiency of β-arrestin-2 resulted in slower migration of breast cancer cells, but little effect on the cell proliferation. Importantly, our data indicated that SUMOylation involves in β-arrestin-2-dependent metabolic regulation, suggesting a potent regulatory pattern for β-arrestin-2-mediated biological functions of tumor cells.
β-arrestin-2 是一种多功能衔接蛋白，最初被鉴定为 G 蛋白介导的信号转导的负调节剂。我们之前揭示了 SUMOylation 作为一种新的机制调节β-arrestin-2 介导的 IL-1R/TRAF6 信号转导。然而，β-arrestin-2 SUMOylation 在肿瘤细胞中的潜在作用尚未完全探索。在本研究中，我们表明β-arrestin-2 的 SUMOylation 缺陷导致乳腺癌细胞迁移速度减慢，但对细胞增殖影响较小。重要的是，我们的数据表明 SUMOylation 涉及β-arrestin-2 依赖性代谢调节，提示β-arrestin-2 介导的肿瘤细胞生物学功能的一种潜在调节模式。
