Benzinger Petra, Bauer Jürgen Martin, Schwenk Michael, Grund Stefan, Goisser Sabine
Center for Geriatric Medicine, AGAPLESION Bethanien Hospital Heidelberg, Heidelberg University Hospital, Heidelberg, Germany
Faculty of Health and Social Sciences, University of Applied Sciences Kempten, Kempten, Germany.
BMJ Open. 2020 Aug 20;10(8):e037531. doi: 10.1136/bmjopen-2020-037531.
Sarcopenia has been recognised as a disease that is consistently associated with a range of geriatric syndromes and negative health consequences. The prevalence of sarcopenia is high among nursing home residents. Several systematic reviews have assessed the efficacy of a range of treatment strategies against sarcopenia. However, no systematic review discussing specifically the treatment options for sarcopenic nursing home residents has been conducted so far. The objective of this scoping review, therefore, is to identify and map existing studies that assessed the feasibility and effectiveness of interventions that were conducted with the aim to treat sarcopenic nursing home residents.
The protocol was developed using an established scoping review methodological framework. A systematic search of relevant literature databases will be conducted. We will also conduct a search of ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform Search Portal for ongoing and recently completed trials, and will search for grey literature. Two reviewers will independently screen titles and abstracts for inclusion, followed by screening of the full text of potentially relevant articles to determine final inclusion. A data extraction sheet will be developed including key study characteristics that will be relevant for collating, summarising and reporting the results of the scoping review.
The proposed scoping review will undertake a secondary analysis of publicly available data, and therefore does not require ethical approval. The results will be disseminated to researchers in the field by submitting the review to a peer-reviewed international journal and by presenting our findings at relevant conferences. We expect that the results of the final review will help to guide future research in the field of sarcopenia treatment for nursing home residents.
肌肉减少症已被公认为一种与一系列老年综合征及不良健康后果持续相关的疾病。养老院居民中肌肉减少症的患病率很高。多项系统评价评估了一系列针对肌肉减少症的治疗策略的疗效。然而，迄今为止，尚未有专门讨论肌肉减少症养老院居民治疗选择的系统评价。因此，本范围综述的目的是识别和梳理现有研究，这些研究评估了旨在治疗肌肉减少症养老院居民的干预措施的可行性和有效性。
本方案采用既定的范围综述方法框架制定。将对相关文献数据库进行系统检索。我们还将检索ClinicalTrials.gov和世界卫生组织国际临床试验注册平台搜索门户，以查找正在进行和最近完成的试验，并将搜索灰色文献。两名评审员将独立筛选标题和摘要以确定是否纳入，随后筛选潜在相关文章的全文以确定最终纳入情况。将制定一份数据提取表，其中包括与整理、总结和报告范围综述结果相关的关键研究特征。
拟议的范围综述将对公开可用的数据进行二次分析，因此无需伦理批准。研究结果将通过将综述提交给同行评审的国际期刊，并在相关会议上展示我们的研究结果，传播给该领域的研究人员。我们预计最终综述的结果将有助于指导未来针对养老院居民肌肉减少症治疗领域的研究。
