UDS activity in the rat liver of the human carcinogens benzidine and 4-aminobiphenyl, and the rodent carcinogens 3,3'-dichlorobenzidine and direct black 38.
作者信息
Ashby J, Mohammed R
机构信息
Imperial Chemical Industries Plc, Central Toxicology Laboratory, Macclesfield, Cheshire, UK.
出版信息
Mutagenesis. 1988 Jan;3(1):69-71. doi: 10.1093/mutage/3.1.69.
PMID:3282145
Abstract
The activity of benzidine and three structurally related carcinogens in an in vivo/in vitro rat liver assay for unscheduled DNA synthesis is described. The first three of these chemicals, benzidine, 4-aminobiphenyl (4AB) and Direct Black 38 have been reported as positive in this assay by other investigators, albeit the data reported for 4AB were limited. The fourth compound, 3,3'-dichlorobenzidine has not been studied in this assay before. Each compound gave a clear positive response under conditions of routine testing.
摘要
相似文献
1
UDS activity in the rat liver of the human carcinogens benzidine and 4-aminobiphenyl, and the rodent carcinogens 3,3'-dichlorobenzidine and direct black 38.
Mutagenesis. 1988 Jan;3(1):69-71. doi: 10.1093/mutage/3.1.69.
2
Benzidine and 3,3'-dichlorobenzidine (DCB) induce micronuclei in the bone marrow and the fetal liver of mice after gavage.
Mutagenesis. 1987 Jul;2(4):267-9. doi: 10.1093/mutage/2.4.267.
3
Using base-specific Salmonella tester strains to characterize the types of mutation induced by benzidine and benzidine congeners after reductive metabolism.使用碱基特异性沙门氏菌测试菌株来表征联苯胺及其同系物在还原代谢后诱导的突变类型。
Food Chem Toxicol. 2001 Dec;39(12):1253-61. doi: 10.1016/s0278-6915(01)00072-2.
4
Evidence that 4-aminobiphenyl, benzidine, and benzidine congeners produce genotoxicity through reactive oxygen species.4-氨基联苯、联苯胺及其同系物通过活性氧产生遗传毒性的证据。
Environ Mol Mutagen. 2007 Jun;48(5):404-13. doi: 10.1002/em.20288.
5
3,3'-Dichlorobenzidine and 3,3'-dichlorobenzidine dihydrochloride.
Rep Carcinog. 2004;11:III87-9.
6
3,3'-Dichlorobenzidine and its dihydrochloride.
IARC Monogr Eval Carcinog Risk Chem Hum. 1982 May;29:238-56.
7
Activation of 3,3'-dichlorobenzidine: enzymic basis and toxicological consequences.
Drug Metab Rev. 1989;21(3):377-400. doi: 10.3109/03602538909030303.
8
Carcinogenicity of azo colorants: influence of solubility and bioavailability.偶氮染料的致癌性：溶解度和生物利用度的影响
Toxicol Lett. 2004 Jun 15;151(1):203-10. doi: 10.1016/j.toxlet.2003.11.016.
9
Mutagenicity of some congeners of benzidine in the Salmonella typhimurium assay system.
Cancer Lett. 1978 Jan;4(1):21-5. doi: 10.1016/s0304-3835(78)93137-3.
10
3,3'-Dichlorobenzidine and 3,3'-dichlorobenzidine dihydrochloride.
Rep Carcinog. 2002;10:85-7.
Zotero 插件