Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
Northern Finland Laboratory Center NordLab, Oulu University Hospital, 90120, Oulu, Finland.
Biol Trace Elem Res. 2021 Jun;199(6):2131-2137. doi: 10.1007/s12011-020-02341-2. Epub 2020 Aug 21.
Preeclampsia, a pregnancy disorder that includes hypertension and proteinuria, is a major cause of maternal and fetal morbidity and mortality. Some studies, but not all, have found that women with preeclampsia have significantly lower iodine levels than healthy pregnant women. Resolving this issue is important because iodine deficiency in pregnancy is common in the USA and parts of Europe including Finland. We conducted a nested case-control study to determine whether the risk for preeclampsia is associated with iodine status. We measured serum iodine, thyroglobulin (Tg), and thyroid stimulating hormone (TSH) at 10-14 weeks gestational age in 204 women with preeclampsia and 246 unaffected controls selected from all births in Finland. We found no significant difference in iodine (case mean = 26.04 ng/mL, control mean = 27.88 ng/mL, p = 0.995), Tg (case mean = 31.11 ng/mL, control mean = 29.61 ng/mL, p = 0.996), and TSH (case mean = 1.30 mIU/L, control mean = 1.24 mIU/L, p = 0.896) levels between cases and controls. There was no significant relationship between preeclampsia risk and iodine, Tg, or TSH after adjustment for known risk factors. These results are reassuring given the high prevalence of iodine deficiency in pregnancy.
子痫前期是一种妊娠疾病，包括高血压和蛋白尿，是孕产妇和胎儿发病率和死亡率的主要原因。一些研究表明，但并非全部研究表明，子痫前期患者的碘水平明显低于健康孕妇。解决这个问题很重要，因为在美国和包括芬兰在内的部分欧洲国家，妊娠期间碘缺乏很常见。我们进行了一项巢式病例对照研究，以确定子痫前期的风险是否与碘状况有关。我们在芬兰所有分娩中选择了 204 名子痫前期患者和 246 名未受影响的对照组，在妊娠 10-14 周时测量了血清碘、甲状腺球蛋白（Tg）和甲状腺刺激激素（TSH）。我们发现碘（病例平均=26.04ng/ml，对照组平均=27.88ng/ml，p=0.995）、Tg（病例平均=31.11ng/ml，对照组平均=29.61ng/ml，p=0.996）和 TSH（病例平均=1.30mIU/L，对照组平均=1.24mIU/L，p=0.896）水平在病例和对照组之间无显著差异。在调整了已知危险因素后，子痫前期风险与碘、Tg 或 TSH 之间没有显著关系。考虑到妊娠期间碘缺乏的高患病率，这些结果令人放心。
