Laboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Laboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Cell. 2020 Aug 20;182(4):796-798. doi: 10.1016/j.cell.2020.07.042.
In this issue of Cell, Molgora et al. and Katzenelenbogen, Sheban, Yalin, et al. highlight the novel role of TREM2 in shaping the immunosuppressive profile of tumor-associated myeloid cells and report that complementing immune-checkpoint therapy with TREM2 blockade induces stronger anti-tumor immune responses and reduces tumor growth.
在本期《细胞》中，Molgora 等人和 Katzenelenbogen、Sheban、Yalin 等人强调了 TREM2 在塑造肿瘤相关髓系细胞免疫抑制特征中的新作用，并报告说，用 TREM2 阻断来补充免疫检查点治疗可诱导更强的抗肿瘤免疫反应并减少肿瘤生长。
