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肥胖和胰岛素抵抗人群中髓系细胞触发受体-1表达增加。

Increased expression of triggering receptor expressed on myeloid cells-1 in the population with obesity and insulin resistance.

作者信息

Subramanian Saravanan, Pallati Pradeep K, Rai Vikrant, Sharma Poonam, Agrawal Devendra K, Nandipati Kalyana C

机构信息

Department of Clinical & Translational Science, Creighton University School of Medicine, Omaha, Nebraska, USA.

Department of Surgery, Creighton University School of Medicine, Omaha, Nebraska, USA.

出版信息

Obesity (Silver Spring). 2017 Mar;25(3):527-538. doi: 10.1002/oby.21714. Epub 2017 Jan 23.

DOI:10.1002/oby.21714
PMID:28111922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5323323/
Abstract

OBJECTIVE

Triggering receptor expressed on myeloid cells (TREM)-1 has recently been recognized as one of the potent amplifiers of acute and chronic inflammation. However, the exact role of TREM-1 in regard to insulin insensitivity is unknown.

METHODS

mRNA transcripts and protein expression of TREM-1, TREM-2, and TREM-1/TREM-2 ratio were examined in the tissue biopsies (liver, omentum, and subcutaneous fat) and blood samples (neutrophils and monocytes) of subjects with obesity and diabetes (SO D ; n = 15), subjects with obesity but not diabetes (SO D ; n = 7), and subjects without obesity (BMI < 30) and diabetes (SO D ; n = 5).

RESULTS

The immunofluorescence and RT-PCR revealed significant increase in TREM-1, decrease in TREM-2, and increase in the TREM1/TREM2 ratio in SO D group compared with other groups. Overall, increased liver TREM-1 expression and soluble-TREM-1 were found in SO D group compared with SO D group (100% vs. 57.14%, r = 0.582; P = 0.023). TREM-1 was significantly increased in all subjects with obesity and those with HOMA-IR index of >2.

CONCLUSIONS

TREM-1 was found to be significantly higher in tissues biopsies and blood of subjects with obesity. Greater expression and activity of TREM-1 suggest a possible role in the underlying pathophysiology of obesity and associated comorbidities.

摘要

目的

髓系细胞触发受体（TREM）-1最近被认为是急性和慢性炎症的强效放大器之一。然而，TREM-1在胰岛素抵抗方面的确切作用尚不清楚。

方法

检测肥胖和糖尿病患者（SO D；n = 15）、肥胖但无糖尿病患者（SO D；n = 7）以及无肥胖（BMI＜30）和糖尿病患者（SO D；n = 5）的组织活检样本（肝脏、网膜和皮下脂肪）和血液样本（中性粒细胞和单核细胞）中TREM-1、TREM-2的mRNA转录本和蛋白表达以及TREM-1/TREM-2比值。

结果

免疫荧光和RT-PCR结果显示，与其他组相比，SO D组中TREM-1显著增加，TREM-2减少，TREM1/TREM2比值增加。总体而言，与SO D组相比，SO D组肝脏TREM-1表达和可溶性TREM-1增加（100%对57.14%，r = 0.582；P = 0.023）。在所有肥胖患者以及HOMA-IR指数＞2的患者中，TREM-1显著增加。

结论

发现肥胖患者的组织活检样本和血液中TREM-1显著升高。TREM-1更高的表达和活性表明其在肥胖及其相关合并症的潜在病理生理学中可能发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8462/5323323/50ae68461026/nihms-828653-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8462/5323323/84fcb6301630/nihms-828653-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8462/5323323/50ae68461026/nihms-828653-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8462/5323323/84fcb6301630/nihms-828653-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8462/5323323/50ae68461026/nihms-828653-f0005.jpg

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本文引用的文献

1
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2
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Front Endocrinol (Lausanne). 2014 Dec 4;5:204. doi: 10.3389/fendo.2014.00204. eCollection 2014.
3
The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis.炎症性肠病发病机制中髓系细胞表达的触发受体（TREM）
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Int J Environ Res Public Health. 2025 Jan 31;22(2):207. doi: 10.3390/ijerph22020207.
4
Modulation of Orosomucoid-like Protein 3 Activity in the Management of Inflammatory Bowel Disease.类orosomucoid蛋白3活性调节在炎症性肠病治疗中的作用
J Biotechnol Biomed. 2024;7(4):433-444. doi: 10.26502/jbb.2642-91280167. Epub 2024 Oct 18.
5
Etiology, Pathophysiology, and Treatment Strategies in the Prevention and Management of Metabolic Syndrome.代谢综合征预防与管理中的病因、病理生理学及治疗策略
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6
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Nat Cardiovasc Res. 2023 Jun 26;2(7):656-672. doi: 10.1038/s44161-023-00295-x.
7
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9
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10
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