葡萄膜炎中的白细胞介素和细胞因子生物标志物

Balamurugan S, Das Dipankar, Hasanreisoglu Murat, Toy Brian C, Akhter Mashal, Anuradha V K, Anthony Eliza, Gurnani Bharat, Kaur Kirandeep

Uveitis Services, Aravind Eye Hospital, Pondicherry, India.

Department of Ocular Pathology, Uveitis and Neuro-Ophthalmology, Sri Sankaradeva Nethralaya, Guwahati, Assam, India.

Indian J Ophthalmol. 2020 Sep;68(9):1750-1763. doi: 10.4103/ijo.IJO_564_20.

Interleukins and cytokines are involved in the pathogenesis of uveitis of heterogeneous origin. Understanding the basics of the ocular immune privilege is a fulcrum to discern their specific role in diverse uveitis to potentially translate as therapeutic targets. This review attempts to cover these elements in uveitis of infectious, noninfectious and masquerade origin. Insights of the molecular targets in novel therapy along with the vision of future research are intriguing.

白细胞介素和细胞因子参与了多种病因所致葡萄膜炎的发病机制。了解眼免疫赦免的基础知识是识别它们在不同类型葡萄膜炎中具体作用的关键，这有可能转化为治疗靶点。本综述试图涵盖感染性、非感染性和伪装综合征性葡萄膜炎的这些方面。新型治疗中分子靶点的见解以及未来研究的展望引人关注。