Babu Kalpana, Dharmanand B G
Department of Uveitis and Ocular Inflammation, Vittala International Institute of Ophthalmology, Prabha Eye Clinic and Research Centre, Bengaluru, Karnataka, India.
Department of Rheumatology, Vikram Hospitals, Bengaluru, Karnataka, India.
Indian J Ophthalmol. 2020 Sep;68(9):1986-1988. doi: 10.4103/ijo.IJO_1644_20.
We report a case of exacerbation of posterior scleritis and orbital pseudotumor in a patient with granulomatosis polyangiitis, with initial rituximab infusion. Modifications in rituximab protocols including reduction in maintenance dose for subsequent infusions with increase in premedication dose of intravenous methyl prednisolone may be useful to prevent periinfusional flares. In this case report, we highlight a rare occurrence and modification in rituximab protocol to prevent post-infusional flare of inflammation.
我们报告了1例肉芽肿性多血管炎患者在初次输注利妥昔单抗后后巩膜炎和眼眶假瘤加重的病例。调整利妥昔单抗方案，包括减少后续输注的维持剂量并增加静脉注射甲泼尼龙的预处理剂量，可能有助于预防输注期间的炎症发作。在本病例报告中，我们强调了利妥昔单抗方案中一种罕见的情况及调整，以预防输注后炎症发作。
