Fernández-Gutiérrez Mar, Pérez-Köhler Bárbara, Benito-Martínez Selma, García-Moreno Francisca, Pascual Gemma, García-Fernández Luis, Aguilar María Rosa, Vázquez-Lasa Blanca, Bellón Juan Manuel
Institute of Polymer Science and Technology, Spanish National Research Council (ICTP-CSIC), 28006 Madrid, Spain.
Biomedical Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain.
Polymers (Basel). 2020 Aug 15;12(8):1829. doi: 10.3390/polym12081829.
The development of a biocomposite polymeric system for the antibacterial coating of polypropylene mesh materials for hernia repair is reported. Coatings were constituted by a film of chitosan containing randomly dispersed poly(d,l-lactide--glycolide) (PLGA) nanoparticles loaded with chlorhexidine or rifampicin. The chlorhexidine-loaded system exhibited a burst release during the first day reaching the release of the loaded drug in three or four days, whereas rifampicin was gradually released for at least 11 days. Both antibacterial coated meshes were highly active against and (10 CFU/mL), displaying zones of inhibition that lasted for 7 days (chlorhexidine) or 14 days (rifampicin). Apparently, both systems inhibited bacterial growth in the surrounding environment, as well as avoided bacterial adhesion to the mesh surface. These polymeric coatings loaded with biodegradable nanoparticles containing antimicrobials effectively precluded bacterial colonization of the biomaterial. Both biocomposites showed adequate performance and thus could have potential application in the design of antimicrobial coatings for the prophylactic coating of polypropylene materials for hernia repair.
报道了一种用于疝修补聚丙烯网片材料抗菌涂层的生物复合聚合物体系的开发。涂层由含有随机分散的负载洗必泰或利福平的聚（d，l-丙交酯-乙交酯）（PLGA）纳米颗粒的壳聚糖膜构成。负载洗必泰的体系在第一天表现出突释，在三到四天内达到负载药物的释放，而利福平则至少在11天内逐渐释放。两种抗菌涂层网片对金黄色葡萄球菌和大肠杆菌（10⁶CFU/mL）均具有高活性，显示出持续7天（洗必泰）或14天（利福平）的抑菌圈。显然，两种体系均抑制了周围环境中的细菌生长，并避免了细菌粘附于网片表面。这些负载有含抗菌剂的可生物降解纳米颗粒的聚合物涂层有效地阻止了生物材料的细菌定植。两种生物复合材料均表现出足够的性能，因此在用于疝修补的聚丙烯材料预防性涂层的抗菌涂层设计中可能具有潜在应用。
