Kim Hye Mi, Kwon Jaeyoung, Lee Kyerim, Lee Jae Wook, Jang Dae Sik, Kwon Hak Cheol
College of Pharmacy, Kyung Hee University, Seoul 02447, Korea.
KIST Gangneung Institute of Natural Products, Korea Institute of Science and Technology (KIST), Gangneung 25451, Korea.
Plants (Basel). 2020 Aug 18;9(8):1051. doi: 10.3390/plants9081051.
is widely used in traditional medicine and contains various types of metabolites with pharmacological activity. In the course of searching for neuroprotective molecules associated with the potential of in the treatment of neurodegenerative disorders, two new phenolic compounds ( and ) and a new tripeptide (), together with 16 known compounds (-), were isolated from the rhizomes of . The structures of the compounds were determined by the interpretation of spectroscopic data, including nuclear magnetic resonance and mass spectrometry data. All obtained compounds were assessed for their ability to protect neuronal cells against neurotoxicity and neuroinflammation. Of these, and were found to possess moderate activities in HT22 hippocampal neuronal cells, whereas , , and showed weak activities in R28 retinal cells. Additionally, compound showed moderate inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells.
它在传统医学中被广泛使用，并且含有多种具有药理活性的代谢产物。在寻找与治疗神经退行性疾病潜力相关的神经保护分子的过程中，从[植物名称]的根茎中分离出了两种新的酚类化合物（[化合物名称1]和[化合物名称2]）、一种新的三肽（[化合物名称3]）以及16种已知化合物（[化合物名称4]-[化合物名称19]）。通过对光谱数据（包括核磁共振和质谱数据）的解析确定了这些化合物的结构。评估了所有获得的化合物保护神经元细胞免受神经毒性和神经炎症影响的能力。其中，[化合物名称1]和[化合物名称2]在HT22海马神经元细胞中具有中等活性，而[化合物名称3]、[化合物名称4]和[化合物名称5]在R28视网膜细胞中表现出较弱的活性。此外，化合物[化合物名称6]对BV2小胶质细胞中脂多糖诱导的一氧化氮产生具有中等抑制活性。
