Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Économiques & Sociales de la Santé & Traitement de l'Information Médicale, 13385 Marseille, France.
ORS PACA, Observatoire Régional de la Santé Provence-Alpes-Côte d'Azur, 13385 Marseille, France.
Nutrients. 2020 Aug 21;12(9):2532. doi: 10.3390/nu12092532.
Coffee is one of the most consumed beverages worldwide. Previous research has demonstrated its neuroprotective effects in the elderly. People coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) experience an accelerated aging process and cognitive impairment, which significantly impair quality of life and may affect disease-related dimensions such as treatment adherence. This study aimed to analyse the relationship between regular coffee intake and neurocognitive performance (NCP) in HIV-HCV coinfected people. We used data from 139 coinfected patients who participated in both the ANRS CO13 HEPAVIH cohort and the HEPAVIH-Psy cross-sectional survey. Linear regression models adjusting for potential sociodemographic (age, gender, educational level), clinical (liver disease status, ongoing HCV treatment, HIV viral load, major depressive disorder) and socio-behavioural (cannabis use) correlates of NCP were used. Our results showed significant, positive associations between elevated coffee intake (ECI) (three or more cups of coffee per day) and NCP in verbal fluency, psychomotor speed (coding) and executive functioning. ECI might therefore preserve neurocognitive functioning in people living with HIV and HCV.
咖啡是全球范围内最受欢迎的饮品之一。先前的研究已经证明了它对老年人的神经保护作用。同时感染人类免疫缺陷病毒 (HIV) 和丙型肝炎病毒 (HCV) 的人会经历加速衰老和认知障碍，这会显著降低生活质量，并可能影响与疾病相关的维度，如治疗依从性。本研究旨在分析经常喝咖啡与 HIV-HCV 合并感染人群的神经认知表现 (NCP) 之间的关系。我们使用了来自 139 名合并感染患者的数据，他们同时参加了 ANRS CO13 HEPAVIH 队列和 HEPAVIH-Psy 横断面调查。我们使用了调整了潜在社会人口统计学（年龄、性别、教育水平）、临床（肝病状况、正在进行的 HCV 治疗、HIV 病毒载量、重度抑郁症）和社会行为学（大麻使用）因素与 NCP 的线性回归模型。我们的结果表明，咖啡摄入量增加（每天三杯或更多杯咖啡）与言语流畅性、精神运动速度（编码）和执行功能的 NCP 之间存在显著的正相关。因此，咖啡摄入可能有助于保护 HIV 和 HCV 感染者的神经认知功能。
