两岁儿童耐药性肺结核脊柱感染：病例报告。

Drug resistant TB spine in a two year old child: A case report.

机构信息

Department of Clinical Research, ICMR - National Institute for Research in Tuberculosis, Chennai, India.

Department of Pulmonology, Institute of Child Health and Hospital for Children, Chennai, India.

出版信息

Indian J Tuberc. 2020 Jul;67(3):374-377. doi: 10.1016/j.ijtb.2019.09.007. Epub 2019 Oct 3.

DOI:10.1016/j.ijtb.2019.09.007

PMID:32825872

Abstract

Spinal tuberculosis (TB) is a disease of high morbidity that is associated with deformity and neurological sequelae, especially in growing children. Children diagnosed with spinal TB need to be monitored closely for clinical improvements. Previous history of antituberculous therapy (ATT), poor adherence to previous ATT, contact with persons having known drug-resistant (DR) TB, or clinical worsening despite regular ATT are strong indicators for the diagnosis of DR TB of the spine. We report a case of spinal DRTB in a two year old child with no previous history of ATT and contact with a person on irregular treatment for drug sensitive TB that did not show regression of the spinal lesions despite standard ATT.

摘要

脊柱结核（TB）是一种高发病率的疾病，与畸形和神经后遗症有关，尤其是在生长中的儿童中。患有脊柱 TB 的儿童需要密切监测临床改善情况。以前有抗结核治疗（ATT）史、以前 ATT 依从性差、与已知耐药（DR）TB 患者接触、或尽管定期 ATT 但病情仍恶化，这些都是脊柱 DR-TB 的强烈诊断指标。我们报告了一例 2 岁儿童的脊柱 DR-TB 病例，该儿童以前没有 ATT 病史，也没有接触过正在接受不规则敏感 TB 药物治疗的人，但尽管进行了标准 ATT，脊柱病变仍未消退。