3号染色体短臂缺失与头颈癌的进展及预后
Chromosome 3p loss in the progression and prognosis of head and neck cancer.
作者信息
Shaikh Mushfiq Hassan, Barrett John W, Khan Mohammed I, Kim Hugh A J, Zeng Peter Y F, Mymryk Joe S, Nichols Anthony C
机构信息
Department of Otolaryngology-Head and Neck Surgery, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Department of Oncology, London Health Sciences Centre, London Regional Cancer Program, London, Ontario, Canada.
Department of Otolaryngology-Head and Neck Surgery, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
出版信息
Oral Oncol. 2020 Aug 19;109:104944. doi: 10.1016/j.oraloncology.2020.104944.
Head and neck squamous cell carcinoma (HNSCC) is characterized by aggressive behavior with a tendency for recurrence and metastasis. Analyses of The Cancer Genome Atlas (TCGA) data and other cohort studies suggest that the loss of the chromosomal 3p arm is a frequent genetic event observed in both human papillomavirus positive and negative HNSCC. Early molecular analyses (i.e. RFLP, CGH) identified three common regions (3p14.2, 3p21.3 and 3p25) that frequently exhibited loss of genetic material on one arm of the 3p chromosome. More recently, next generation sequencing has revealed the loss of larger regions of this arm. Here we review the role of chromosomal 3p arm loss in early initiation and progression of HNSCC, and its relationship with poor patient prognosis.
头颈部鳞状细胞癌（HNSCC）的特点是具有侵袭性，有复发和转移倾向。对癌症基因组图谱（TCGA）数据及其他队列研究的分析表明，3号染色体短臂缺失是在人乳头瘤病毒阳性和阴性的HNSCC中均观察到的常见基因事件。早期分子分析（即限制性片段长度多态性、比较基因组杂交）确定了三个常见区域（3p14.2、3p21.3和3p25），这些区域在3号染色体短臂的一条臂上经常出现遗传物质缺失。最近，新一代测序揭示了该短臂更大区域的缺失。在此，我们综述3号染色体短臂缺失在HNSCC早期发生和进展中的作用及其与患者预后不良的关系。
Zotero 插件