Department of Neurology, Medical University of Vienna, Vienna, Austria.
Department of Neurology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Trends Mol Med. 2020 Oct;26(10):895-897. doi: 10.1016/j.molmed.2020.07.007. Epub 2020 Aug 20.
PRDM12 is a newly identified causative gene for a type of congenital insensitivity to pain disorder, which is characterized by the inability to perceive pain. Here, we discuss the (patho)physiology of PRDM12 function and the opportunities and challenges those data provide for novel therapeutic approaches in various pain disorders.
PRDM12 是一种新发现的先天性无痛症的致病基因，其特征是无法感知疼痛。在这里，我们讨论了 PRDM12 功能的（病理）生理学，以及这些数据为各种疼痛障碍的新型治疗方法提供的机会和挑战。
