Kishimoto Y, Maeda R, Ushiba D
Jikken Dobutsu. 1977 Apr;26(2):115-21.
A congenic strain of mice (DKIR) having a relatively resistant gene for mouse typhoid was established by the beckcross mating between C3H/He and DKI strains. DKI strain is highly and uniformly susceptible to the infection with Salmonella enteritidis and C3H/He is relatively resistant to that infection. The present paper reported the consistency of resistance to Salmonella infection of DKIR strain throughout generations after 10 backcross matings. Difference of the number of infected organisms in the peritoneal fluid and organs between DKIR and DKI or C3H/He strains was also described. The newly established DKIR strain seems to be a suitable experimental animal for the study of genetical resistance for mouse typhoid when compared with its original DKI strain.
通过C3H/He和DKI品系之间的回交交配，建立了对鼠伤寒具有相对抗性基因的近交系小鼠（DKIR）。DKI品系对肠炎沙门氏菌感染高度且一致易感，而C3H/He对该感染相对抗性。本文报道了经过10次回交交配后，DKIR品系对沙门氏菌感染的抗性在各代中的一致性。还描述了DKIR与DKI或C3H/He品系在腹膜液和器官中感染菌数量的差异。与原始的DKI品系相比，新建立的DKIR品系似乎是研究鼠伤寒遗传抗性的合适实验动物。
