Discipline of Orthoptics, College of Science, Health and Engineering, La Trobe University, Melbourne, Victoria, Australia.
Clin Exp Ophthalmol. 2020 Dec;48(9):1286-1298. doi: 10.1111/ceo.13845. Epub 2020 Nov 2.
The purpose of this study was to review adherence rates to intravitreal injections in the treatment of diabetic macula oedema and to identify factors associated with adherence. A systematic search of Embase, Medline, PsycINFO and CINAHL was conducted up to May 2020. Two authors independently screened, selected and appraised the studies. Seven articles on anti-VEGF treatment were found to meet the inclusion criteria. No studies were found on intravitreal corticosteroids or dexamethasone implants. Attendance rates varied between studies from 35% to 85%. The rate of missed or delayed attendance ranged from 14% to 51%, whereas 25% of patients were lost to follow-up at 12 months. Non-adherence was found to be multifactorial and included patient related reasons, demographic characteristics and clinical factors. Enablers to adherence included patient understanding of the disease and treatment. Further research in this area is warranted in order to better understand adherence in these patients and to improve patient outcomes.
本研究旨在回顾玻璃体内注射治疗糖尿病黄斑水肿的依从率，并确定与依从性相关的因素。系统检索了 Embase、Medline、PsycINFO 和 CINAHL，检索截至 2020 年 5 月。两名作者独立筛选、选择和评价了研究。有 7 篇关于抗 VEGF 治疗的文章符合纳入标准。未发现关于玻璃体内皮质类固醇或地塞米松植入物的研究。不同研究的就诊率从 35%到 85%不等。漏诊或延迟就诊的比例从 14%到 51%不等，而 12 个月时 25%的患者失访。不依从是多因素的，包括患者相关原因、人口统计学特征和临床因素。依从性的促进因素包括患者对疾病和治疗的理解。需要在这一领域进行进一步的研究，以更好地了解这些患者的依从性，并改善患者的预后。
