School of Pharmaceutical Sciences, MOE Key Laboratory of, Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, 100084, P. R. China.
Department of Chemistry, University of Science and Technology of China, Hefei, 230026, P. R. China.
Chemistry. 2020 Dec 18;26(71):17011-17015. doi: 10.1002/chem.202003506. Epub 2020 Nov 18.
Catalytic, enantioselective synthesis of stereogenic silicon compounds remains a challenge. Herein, we report a rhodium-catalyzed regio- and enantio-selective intermolecular hydrosilylation of alkene with prochiral dihydrosilane. This new method features a simple catalytic system, mild reaction conditions and a wide functional group tolerance.
手性硅化合物的催化、对映选择性合成仍然是一个挑战。在此，我们报告了一种铑催化的区域和对映选择性的烯烃与前手性二氢硅烷的分子间氢硅化反应。这种新方法具有简单的催化体系、温和的反应条件和广泛的官能团容忍度。
