Zhu Xiao-Yan, Gao Wenyu, Xu Jian-Lin, Wang Zi-Lu, Zhao Jin-Bo, Xu Yun-He
Department of Chemistry, University of Science and Technology of China, Hefei, PR China.
Faculty of Chemistry and Life Science, Changchun University of Technology, Changchun, PR China.
Nat Commun. 2025 Jan 3;16(1):378. doi: 10.1038/s41467-024-55592-1.
This study presents a copper-catalyzed, substrate-controlled regio- and enantioselective intermolecular hydrosilylation method capable of accommodating a broad scope of alkenes and prochiral silanes. The approach offers an efficient and versatile pathway to generate enantioenriched linear and branched alkyl-substituted Si-stereogenic silanes. Key features of this reaction include mild reaction conditions, simple catalytic systems, compatibility with diverse substrates, high yields and enantioselectivities.
本研究提出了一种铜催化、底物控制的区域和对映选择性分子间硅氢化方法，该方法能够适用于多种烯烃和前手性硅烷。该方法提供了一条高效且通用的途径来生成对映体富集的直链和支链烷基取代的硅立体中心硅烷。该反应的关键特征包括温和的反应条件、简单的催化体系、与各种底物的兼容性、高收率和对映选择性。
