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本文引用的文献

1
Unusual manifestation of cutaneous toxoplasmosis in a HIV-positive patient.一名艾滋病毒阳性患者皮肤弓形虫病的不寻常表现。
Trop Biomed. 2010 Dec;27(3):447-50.
2
Structures of Toxoplasma gondii tachyzoites, bradyzoites, and sporozoites and biology and development of tissue cysts.刚地弓形虫速殖子、缓殖子和子孢子的结构以及组织包囊的生物学特性与发育
Clin Microbiol Rev. 1998 Apr;11(2):267-99. doi: 10.1128/CMR.11.2.267.
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表现为不愈合皮肤溃疡的弓形虫病

Toxoplasmosis Presenting as Nonhealing Cutaneous Ulcer.

作者信息

Adhikari M, Dhakal S, Bhattarai S, Rai U

机构信息

Department of Pathology, BPKIHS, Nepal.

出版信息

Case Rep Pathol. 2020 Aug 3;2020:8874800. doi: 10.1155/2020/8874800. eCollection 2020.

DOI:10.1155/2020/8874800
PMID:32832183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7424535/
Abstract

INTRODUCTION

Systemic manifestation of toxoplasmosis is commonly seen in immune-compromised individuals. Skin manifestations are seen commonly in conjunction with systemic features. Isolated cutaneous toxoplasmosis is extraordinarily rare in immunocompetent patients. . A 64-year-old female presented to the Dermatology Outpatient Department (OPD), with a nonhealing ulcer over dorsum of the left hand for one year. The patient did not have any systemic diseases. Serology tests were negative. An incisional biopsy of the lesion revealed dense inflammatory cell infiltrates comprising predominantly of plasma cells and lymphocytes, multinucleated giant cells, and focal abscess formation in the dermis. Periodic Acid Schiff (PAS) stain showed organisms in the dermis with morphological resemblance to tachyzoites of Toxoplasma gondii.

CONCLUSION

Though rare, a possibility of primary cutaneous toxoplasmosis should always be considered and looked for, even in immunocompetent patients presenting with chronic nonhealing ulcers.

摘要

引言

弓形虫病的全身表现常见于免疫功能低下的个体。皮肤表现通常与全身特征同时出现。在免疫功能正常的患者中,孤立性皮肤弓形虫病极为罕见。一名64岁女性因左手背一处不愈合溃疡就诊于皮肤科门诊,病程长达一年。该患者无任何全身性疾病。血清学检查呈阴性。对病变进行切开活检,结果显示真皮层有密集的炎性细胞浸润,主要由浆细胞和淋巴细胞、多核巨细胞组成,并伴有局灶性脓肿形成。过碘酸希夫(PAS)染色显示真皮层内有形态与刚地弓形虫速殖子相似的生物体。

结论

尽管罕见,但即使在出现慢性不愈合溃疡的免疫功能正常患者中,也应始终考虑并排查原发性皮肤弓形虫病的可能性。