Correlation of Immunological Markers with Disease and Clinical Outcome Measures in Patients with Autoimmune Retinopathy.

PURPOSE

To determine if immunological markers (1) are significantly different between autoimmune retinopathy (AIR) patients and controls and (2) correlate with disease progression in AIR patients.

METHODS

We enrolled patients with a possible AIR diagnosis, as well as control participants without eye disease, autoimmunity, or cancer. Immunological markers were tested in all participants. In addition, AIR patients had up to three blood draws for testing over their disease course. For AIR patients, clinical measures, including visual acuity (VA) and Goldmann visual field (GVF) area, were recorded at each draw. We used the Mann-Whitney test to compare the immunological markers between AIR patients and controls. We used multilevel mixed-effect regression to investigate the correlation between markers and clinical parameters over time in AIR patients.

RESULTS

Seventeen patients with AIR and 14 controls were included. AIR patients had a higher percent of monocytes ( = 3.076, = 0.002). An increase in immunoglobulin G against recoverin was correlated with a VA decrease (β = 0.0044, < 0.0001). An increase in monocyte proportion was correlated with a decrease in GVF area (β = -7.27, = 0.0021). Several markers of B-cell depletion were correlated with GVF improvement.

CONCLUSIONS

Monocytes may play a role in AIR pathophysiology and be a disease activity marker. B-cell depletion markers correlated with clinical parameter improvement, particularly GVF.

TRANSLATIONAL RELEVANCE

This work elucidates immunologic markers that may improve the accuracy of diagnosis and treatment of AIR.