La Marca A, Capuzzo M, Bartolucci S, Schirinzi F, Dal Canto M B, Buratini J, Mignini Renzini M, Rodriguez A, Vassena R
Clinica EUGIN, Via Nobili 188/F, 41126 Modena, Italy.
Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Largo del Pozzo 71, 41123 Modena, Italy.
Facts Views Vis Obgyn. 2020 Aug 5;12(2):111-118.
As highlighted by European statistics, the employment of donor oocytes is a growing option for women who cannot make use of their own gametes. As the potential recipients are continuously increasing in number, a donor programme which satisfies this demand is mandatory. Improvements in cryopreservation techniques, like oocyte and embryo vitrification, have led to the overcoming of the sequence of stimulation-retrieval-transfer both from a spatial and a temporal point of view, with the development of cryobanks of oocytes permitting crossborder donation. However, while some studies report comparable success when using vitrified and fresh oocytes we still need to investigate whether the use of fresh oocytes give higher live birth rate than cryopreserved ones, when the same number of oocytes are given. The performance of embryo cryopreservation, conversely, seems to be more reliable. A novel approach based on the shipment of frozen sperm from the recipient's country to the oocyte donor's one, where fresh oocytes are inseminated and the resulting embryos frozen and transported back to the referring IVF centre to perform a frozen embryo transfer may be a good strategy. We believe that the use of frozen embryos from fresh oocytes could be associated with a higher cumulative live birth rate per cycle, while favouring personalised oocyte recipient care with a flexible number of oocytes assigned and limiting the burden of travelling abroad.
正如欧洲统计数据所强调的，对于无法使用自身配子的女性而言，使用捐赠卵母细胞正成为越来越多的选择。随着潜在受者数量持续增加，一个满足这一需求的捐赠计划是必不可少的。冷冻保存技术的改进，如卵母细胞和胚胎玻璃化冷冻，从空间和时间角度都克服了刺激-取卵-移植的顺序，随着卵母细胞冷冻库的发展，跨境捐赠得以实现。然而，虽然一些研究报告称使用玻璃化冷冻和新鲜卵母细胞的成功率相当，但当提供相同数量的卵母细胞时，我们仍需研究使用新鲜卵母细胞的活产率是否高于冷冻保存的卵母细胞。相反，胚胎冷冻保存的表现似乎更可靠。一种新的方法是将冷冻精子从受者所在国家运往卵母细胞捐赠者所在国家，在那里用新鲜卵母细胞进行授精，将 resulting embryos 冷冻并运回转诊的体外受精中心进行冷冻胚胎移植，这可能是一个好策略。我们认为，使用来自新鲜卵母细胞的冷冻胚胎可能与每个周期更高的累积活产率相关，同时有利于个性化的卵母细胞受者护理，分配灵活数量的卵母细胞，并减轻出国旅行的负担。
（注：原文中“resulting embryos”表述有误，推测可能是“resulting embryos”，翻译时保留了错误表述。）
