普萘洛尔及长效普萘洛尔治疗特发性震颤：一项双盲对照研究。
Propranolol and propranolol-LA in essential tremor: a double blind comparative study.
作者信息
Cleeves L, Findley L J
机构信息
MRC Neuro-Otology Unit, National Hospital, Queen Square, London, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1988 Mar;51(3):379-84. doi: 10.1136/jnnp.51.3.379.
Abstract
In a double blind, comparative study with 15 patients, a long-acting formulation of propranolol taken once daily (at doses of 160, 240 and 320 mg), was shown to be as effective as conventional propranolol (80 mg three times daily) in reducing the amplitude of essential tremor. The specific protocol employed demonstrated problems inherent in chronic pharmacological trials in essential tremor which have implications for future studies.
摘要
在一项针对15名患者的双盲对照研究中，每日服用一次的长效普萘洛尔制剂（剂量分别为160毫克、240毫克和320毫克）在减轻特发性震颤幅度方面，被证明与常规普萘洛尔（每日三次，每次80毫克）效果相当。所采用的具体方案揭示了特发性震颤慢性药理学试验中固有的问题，这些问题对未来的研究具有启示意义。
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本文引用的文献
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