Women's Health Sciences Division, National Center for PTSD, Research Service, VA Boston Healthcare System.
National Center for PTSD, VA Boston Healthcare System.
Health Psychol. 2020 Sep;39(9):826-840. doi: 10.1037/hea0000876.
This study utilizes the Science of Behavior Change (SOBC) experimental medicine approach to evaluate the effects of a 3-month, individually prescribed progressive exercise training program on neurobiological, cognitive and motivational mechanisms by which our exercise-training paradigm may foster exercise maintenance. We will investigate hypothesized relationships between exercise-training associated augmentation of neuropeptide Y (NPY) system function and improvements in self-regulation and reward sensitivity-cognitive control and motivational processes posited to promote self-efficacy and intrinsic motivation, which have been shown to predict exercise maintenance. This study will recruit Veterans with chronic low back pain and posttraumatic stress disorder (PTSD). Procedures include a baseline, acute cardiopulmonary exercise challenge assessment that will inform the exercise prescription for a 12-week progressive exercise training program comprised of three 45-minute aerobic exercise sessions per week-all of which will be supervised by an exercise physiologist. Additionally, a week-7 and week-14 exercise challenge assessment will track changes in NPY system function and the variables of interest. We hypothesize that increases in the capacity to release NPY in response to acute exercise testing will be associated with improvements in self-regulation and reward sensitivity, which will in turn be associated with self-efficacy and intrinsic motivation to maintain regular exercise. Ninety participants will be randomized either to the "active exercise training condition" or to the "wait list symptom monitoring condition". The study aims to demonstrate the feasibility of procedures and elucidate mechanisms relevant to developing individually prescribed, motivationally based exercise regimens to reduce negative consequences of PTSD and low back pain over the long-term. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
本研究利用行为改变科学（SOBC）实验医学方法，评估为期 3 个月的个体化渐进性运动训练方案对神经生物学、认知和动机机制的影响，而我们的运动训练模式可能通过这些机制促进运动维持。我们将研究运动训练与神经肽 Y（NPY）系统功能增强之间的假设关系，以及自我调节和奖励敏感性-认知控制和动机过程的改善，这些过程被认为可以促进自我效能感和内在动机，这些因素已被证明可以预测运动的维持。本研究将招募患有慢性下背痛和创伤后应激障碍（PTSD）的退伍军人。程序包括基线、急性心肺运动挑战评估，这将为 12 周的渐进性运动训练计划提供运动处方，该计划由每周三次、每次 45 分钟的有氧运动组成，所有运动都将由运动生理学家监督。此外，每周 7 天和第 14 天的运动挑战评估将跟踪 NPY 系统功能和感兴趣变量的变化。我们假设，对急性运动测试中 NPY 释放能力的增加将与自我调节和奖励敏感性的改善相关，而自我调节和奖励敏感性的改善又将与保持规律运动的自我效能感和内在动机相关。90 名参与者将被随机分配到“主动运动训练组”或“等待名单症状监测组”。该研究旨在证明程序的可行性，并阐明与制定个体化、基于动机的运动方案相关的机制，以减轻 PTSD 和慢性下背痛的长期负面影响。（PsycInfo 数据库记录（c）2020 APA，保留所有权利）。
