Jin Aihua, Yan Benyong, Hua Wei, Feng Dandan, Xu Bin, Liang Lianchun, Guo Caiping
C8 Ward, Infection Center, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
Biosaf Health. 2020 Jun;2(2):104-111. doi: 10.1016/j.bsheal.2020.05.003. Epub 2020 May 12.
This study aimed to determine the clinical characteristics of patients diagnosed with the coronavirus disease 2019 (COVID-19). Clinical data of COVID-19 patients diagnosed between January 28, 2020 and February 23, 2020 at the Beijing You'an Hospital were summarized and analyzed. Overall, 45 (18 men and 27 women) patients were included in this study. The average age of patients was 58 years (range, 7-94 years). Furthermore, 21 patients (47%) experienced underlying chronic diseases, with another four patients (9%) having three or more chronic diseases simultaneously. The first symptoms appeared at the onset of illness onset include fever in 36 patients (80%), cough in 23 patients (51%), and expectoration in 15 patients (33%), respectively. Patients may experience hepatic and renal injury as well as abnormal myocardial enzymes in varying degrees. Senior patients (≥58) and accompanying chronic diseases were considered as independent predictors for developing a severe and critically ill population with increased mortality. Laboratory results regarding the NEU percentage, NLR, ALC, and C-reactive protein levels were considered significant in predicting clinically critical disease or for prognosis assessment and thus require further studies. COVID-19 may affect multiple organs of the human body. Glucocorticoid is considered effective in the treatment of patients diagnosed with severe COVID-19.
本研究旨在确定2019冠状病毒病(COVID-19)确诊患者的临床特征。对2020年1月28日至2020年2月23日在北京佑安医院确诊的COVID-19患者的临床资料进行了总结和分析。本研究共纳入45例患者(18例男性和27例女性)。患者的平均年龄为58岁(范围为7至94岁)。此外,21例患者(47%)患有基础慢性病,另有4例患者(9%)同时患有三种或更多慢性病。发病初期出现的首发症状分别为发热36例(80%)、咳嗽23例(51%)、咳痰15例(33%)。患者可能会出现不同程度的肝肾功能损伤以及心肌酶异常。老年患者(≥58岁)和伴有慢性病被认为是发展为重症和危重症人群、死亡率增加的独立预测因素。关于中性粒细胞百分比、中性粒细胞与淋巴细胞比值、淋巴细胞绝对值和C反应蛋白水平的实验室结果在预测临床危重病或评估预后方面具有重要意义,因此需要进一步研究。COVID-19可能会影响人体的多个器官。糖皮质激素被认为对确诊为重症COVID-19的患者治疗有效。