Ophthalmology Department, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Ocul Immunol Inflamm. 2022 Jan 2;30(1):234-240. doi: 10.1080/09273948.2020.1794011. Epub 2020 Aug 24.
To evaluate the efficacy of Ozurdex implant by analyzing macular morphology and function in pediatric uveitis and related cystoid macular edema (CMO).
Main outcomes were visual acuity, mfERG and photopic ERG response, and central macular thickness. Mean values recorded at each time-point were compared to baseline and correlations between functional and anatomical parameters were evaluated.
Resolution of intraocular inflammation and CMO was achieved in all eyes 1 month after implant without procedure or drug-related complications. Mean visual acuity and mfERG amplitude improved showing a statistically significant difference to baseline values for the first 4 months. Mean central macular thickness showed a statistically significant reduction for all follow-up time. Photopic ERG did not vary significantly. Statistically significant correlation was found between trends of visual acuity, central macular thickness, and mfERG responses.
Correlation found between macular morphology and function confirms the efficacy of Ozurdex in pediatric uveitis.
通过分析小儿葡萄膜炎及相关囊样黄斑水肿（CMO）的黄斑形态和功能，评估 Ozurdex 植入物的疗效。
主要观察指标为视力、mfERG 和明视 ERG 反应以及中心黄斑厚度。在每个时间点记录的平均值与基线进行比较，并评估功能和解剖参数之间的相关性。
植入后 1 个月，所有眼均实现了眼内炎症和 CMO 的消退，无手术或药物相关并发症。平均视力和 mfERG 振幅在头 4 个月内均有显著改善，与基线值相比具有统计学意义。所有随访时间的平均中央黄斑厚度均有显著降低。明视 ERG 无显著变化。视力、中央黄斑厚度和 mfERG 反应的趋势之间存在显著相关性。
黄斑形态和功能之间的相关性证实了 Ozurdex 在小儿葡萄膜炎中的疗效。
