Soares Maísa Carvalho Rezende, Silva Mayara Cristina Pinto, Almeida-Junior Francisco de Assis da Silva, Nascimento Johnny Ramos, Nascimento Flavia Raquel Fernandes, Guerra Rosane Nassar Meireles
University Center of Maranhão - CEUMA, São Luís, Brazil.
CCBS-Laboratory of Immunophysiology, Federal University of Maranhão, São Luís, Brazil.
J Med Food. 2021 Apr;24(4):411-421. doi: 10.1089/jmf.2020.0071. Epub 2020 Aug 24.
The population widely uses babassu mesocarp () as food and medicine. This study evaluated the use of babassu mesocarp as a food supplement during resistance training (RT). Male Swiss mice, 60 days old (weight 35-40 g), were divided into four groups ( = 8): control, untreated and untrained; babassu (babassu aqueous extract [BAE]), treated orally with aqueous extract of babassu mesocarp (25 mg/kg), five times a week, for 8 weeks; training (RT), submitted to RT consisting of stair climbing with progressive loads; and resistance training treated with babassu aqueous extract (RTBAE): RT and treatment with BAE. After 8 weeks, we analyzed the biochemistry of serum, the immunological, and histological parameters. The RT group showed maximum strength after the second week. A reduction in body weight, retroperitoneal and interstitial fat deposits, and activated helper T lymphocytes (TCD4+ CD69+) occurred in RT and RTBAE groups. The RTBAE group showed increased levels of aspartate aminotransferase, alanine aminotransferase, and macrophage and helper T lymphocyte count, whereas a reduction occurred in triglyceride levels and the total number of lymphocytes. Supplementation with BAE always reduced cholesterol and the population of activated macrophages but increased activated B lymphocytes and interleukin-6 levels. The combination of supplementation and RT resulted in a decreased production of tumor necrosis factor-. We propose the use of babassu mesocarp as a food supplement during exercise because of its immunomodulatory effect on lymphocyte and macrophage populations and cytokine production. The additional impact on the control of cholesterol and triglyceride levels suggests its use, particularly for the treatment of dyslipidemias.
人们广泛将巴巴苏中果皮用作食物和药物。本研究评估了巴巴苏中果皮作为抗阻训练（RT）期间食物补充剂的作用。60日龄雄性瑞士小鼠（体重35 - 40克）被分为四组（每组n = 8）：对照组，未处理且未训练；巴巴苏组（巴巴苏水提取物[BAE]），每周口服巴巴苏中果皮水提取物（25毫克/千克）5次，共8周；训练组（RT），进行由渐进负荷爬楼梯组成的抗阻训练；抗阻训练并用巴巴苏水提取物组（RTBAE）：进行抗阻训练并使用BAE处理。8周后，我们分析了血清生化、免疫学和组织学参数。RT组在第二周后显示出最大力量。RT组和RTBAE组出现体重、腹膜后和间质脂肪沉积减少，以及辅助性T淋巴细胞活化（TCD4 + CD69 +）。RTBAE组天冬氨酸转氨酶、丙氨酸转氨酶、巨噬细胞和辅助性T淋巴细胞计数水平升高，而甘油三酯水平和淋巴细胞总数减少。补充BAE总是降低胆固醇和活化巨噬细胞数量，但增加活化B淋巴细胞和白细胞介素 - 6水平。补充剂与抗阻训练相结合导致肿瘤坏死因子 - 的产生减少。由于其对淋巴细胞和巨噬细胞群体以及细胞因子产生的免疫调节作用，我们建议在运动期间使用巴巴苏中果皮作为食物补充剂。对胆固醇和甘油三酯水平控制的额外影响表明其用途，特别是用于治疗血脂异常。
