Fu Jingwen, Wu Zhaoyi, Liu Jianfeng, Wu Tianfu
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, People's Republic of China.
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, People's Republic of China.
Biomed Pharmacother. 2020 Nov;131:110588. doi: 10.1016/j.biopha.2020.110588. Epub 2020 Aug 21.
Vitamin C is an electron donor and is involved in a variety of biochemical reactions in stem cell and cancer stem cell, as well as collagen synthesis and the regulation of hypoxia-inducible factor synthesis, which two affect extracellular matrix remodelling and hence cancer metastasis. Specific doses of vitamin C can stop cancer cell glycolysis and block nitroso synthesis, indicating the potential of vitamin C in cancer treatment. Recent studies preliminary revealed Vitamin C enhance the cancer's immune response to anti PD-L1 therapy through multiple indirect approaches. Herein we reviewed the recent function of vitamin C for further research in sequential aspects of cancer stem cell, extracellular matrix remodeling, cancer metastasis and cancer immunotherapy.
维生素C是一种电子供体，参与干细胞和癌症干细胞中的多种生化反应，以及胶原蛋白合成和缺氧诱导因子合成的调节，这两者会影响细胞外基质重塑，进而影响癌症转移。特定剂量的维生素C可以阻止癌细胞的糖酵解并阻断亚硝基合成，这表明维生素C在癌症治疗中具有潜力。最近的研究初步揭示，维生素C通过多种间接途径增强癌症对抗PD-L1疗法的免疫反应。在此，我们综述了维生素C的最新功能，以便在癌症干细胞、细胞外基质重塑、癌症转移和癌症免疫治疗的后续研究方面进行进一步研究。
