Jehn U, Knüppel W, Wilmanns W
Med. Klinik III, Ludwig-Maximilians-Universität München, Klinikum Grosshadern, FRG.
Onkologie. 1988 Feb;11(1):13-7. doi: 10.1159/000216473.
Sixty-three AML patients were entered into a randomized, prospective trial to investigate the impact of intensive maintenance treatment on remission duration and survival. The maintenance program consisted of either a rotating combination of alternative drugs (HD-Ara C, mAMSA, 5-AZA) not used during induction and consolidation or, alternatively, of a repeated induction type chemotherapy early after consolidation (DNM, VCR, Ara C). In 48 out of 63 patients reaching CR, no prolongation of either remission duration or survival was achieved as compared to a preceding randomized study using conventional maintenance treatment.
63例急性髓系白血病患者进入一项随机前瞻性试验，以研究强化维持治疗对缓解期和生存期的影响。维持方案包括诱导和巩固治疗期间未使用的替代药物（大剂量阿糖胞苷、胺苯吖啶、5-氮杂胞苷）的轮换联合使用，或者在巩固治疗后早期进行重复诱导型化疗（柔红霉素、长春新碱、阿糖胞苷）。与之前使用传统维持治疗的随机研究相比，在63例达到完全缓解的患者中，有48例患者的缓解期和生存期均未延长。
