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具有柔性核碱基的核苷类似物。

Nucleoside Analogs with Fleximer Nucleobase.

作者信息

Chudinov Mikhail V

机构信息

MIREA - Russian Technological University, Lomonosov Institute of Fine Chemical Tehnology, 78 Vernadsky Ave, Moscow, 119454 Russia.

出版信息

Chem Heterocycl Compd (N Y). 2020;56(6):636-643. doi: 10.1007/s10593-020-02713-5. Epub 2020 Jul 16.

DOI:10.1007/s10593-020-02713-5
PMID:32836313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7364132/
Abstract

This review article is devoted to the so-called fleximer nucleoside analogs, containing two or more planar moieties in the heterocyclic base, connected by a bond that permits rotation. Such analogs have been proposed as molecular probes for detecting enzyme-substrate interactions and studying the transcription and translation of nucleic acids, but subsequently have attracted the interest of researchers by their antiviral and antitumor activity. The methods used in the synthesis of such compounds, along with their structural features and also biological activity are considered in this review.

摘要

这篇综述文章致力于所谓的柔性核苷类似物，其杂环碱基中含有两个或更多个平面部分，通过允许旋转的键相连。这类类似物已被提议作为检测酶-底物相互作用以及研究核酸转录和翻译的分子探针，但随后因其抗病毒和抗肿瘤活性而引起了研究人员的兴趣。本文综述了这类化合物的合成方法、结构特征以及生物活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/5a648a85c9b3/10593_2020_2713_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/0acd39f45164/10593_2020_2713_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/bba7fd73de60/10593_2020_2713_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/8c6990e61018/10593_2020_2713_Sch3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/bee7bfe85d49/10593_2020_2713_Sch4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/747b2eb755dd/10593_2020_2713_Sch5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/72feb4792c91/10593_2020_2713_Sch6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/739e4ea46499/10593_2020_2713_Sch7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/0b78588884b2/10593_2020_2713_Sch8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/6c303524e344/10593_2020_2713_Sch9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/b0c81af767c5/10593_2020_2713_Sch10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/5ebfac100b1c/10593_2020_2713_Sch11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/e8a84a386c30/10593_2020_2713_Sch12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/d21d3cbaa677/10593_2020_2713_Sch13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/ce64ba03e91a/10593_2020_2713_Sch14_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/dbf7adf05ca0/10593_2020_2713_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/0afee51300a4/10593_2020_2713_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/5a648a85c9b3/10593_2020_2713_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/0acd39f45164/10593_2020_2713_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/bba7fd73de60/10593_2020_2713_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/8c6990e61018/10593_2020_2713_Sch3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/bee7bfe85d49/10593_2020_2713_Sch4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/747b2eb755dd/10593_2020_2713_Sch5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/72feb4792c91/10593_2020_2713_Sch6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/739e4ea46499/10593_2020_2713_Sch7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/0b78588884b2/10593_2020_2713_Sch8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/6c303524e344/10593_2020_2713_Sch9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/b0c81af767c5/10593_2020_2713_Sch10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/5ebfac100b1c/10593_2020_2713_Sch11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/e8a84a386c30/10593_2020_2713_Sch12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/d21d3cbaa677/10593_2020_2713_Sch13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/ce64ba03e91a/10593_2020_2713_Sch14_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/dbf7adf05ca0/10593_2020_2713_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/0afee51300a4/10593_2020_2713_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9459/7364132/5a648a85c9b3/10593_2020_2713_Fig3_HTML.jpg

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