肌生成抑制素基因rs1805086变异与墨西哥成年人的肥胖相关，独立于代谢风险因素。

The myostatin rs1805086 variant is associated with obesity in Mexican adults, independently of metabolic risk factors.

作者信息

Curiel-Cervantes Vianney, Solís-Sáinz Juan C, Costa-Urrutia Paula, Aguilar-Galarza Adriana, Flores-Viveros Karla L, García-Gasca Teresa de Jesús, Anaya-Loyola Miriam A

机构信息

Department of Natural Sciences, Autonomous University of Queretaro, Campus Juriquilla, Queretaro, Mexico.

Department of Biomedical Research, School of Medicine, Autonomous University of Queretaro, Campus La Capilla, Queretaro, Mexico.

出版信息

Biomarkers. 2020 Nov;25(7):566-572. doi: 10.1080/1354750X.2020.1814413. Epub 2020 Sep 23.

DOI:10.1080/1354750X.2020.1814413

PMID:32838566

Abstract

AIM

To determine whether rs1805086 is associated with obesity and metabolic disturbances in a Mexican adult population.

SUBJECTS AND METHODS

We genotyped rs1805086 in 1024 men and women aged 18-58 years. Anthropometric and body fat data were used to estimate obesity. Biochemical parameters were measured and DNA was used to determine the rs1805086 genotype.

RESULTS

rs1805086 heterozygous AG frequency was 5.4%, and the homozygous for the risk allele GG was absent. Heterozygous had higher levels of body mass index (BMI) and waist/height ratio (WHtR). Heterozygous subjects showed a greater total and central obesity compared to the homozygous for ancestral allele AA (OR BMI > 30 kg/m 2.35, 95% CI 1.29-4.29; OR WHtR > 0.5 = 2.03, 95% CI 1.19-3.45; OR elevated fat mass (EFM) %= 1.72, 95% CI 1.01-2.92; OR fat mass index (FMI)>p85 = 1.96, 95% CI 1.05-3.68). rs1805086 was not associated with metabolic alterations.

CONCLUSION

Heterozygosity for rs1805086 showed a predisposition to having elevated overall and central obesity parameters. This association with adiposity seems to be independent of metabolic risk.

摘要

目的

确定rs1805086是否与墨西哥成年人群的肥胖及代谢紊乱相关。

对象与方法

我们对1024名年龄在18 - 58岁的男性和女性进行了rs1805086基因分型。使用人体测量和体脂数据评估肥胖情况。测量生化参数，并使用DNA确定rs1805086基因型。

结果

rs1805086杂合子AG频率为5.4%，风险等位基因GG的纯合子未出现。杂合子的体重指数（BMI）和腰高比（WHtR）水平较高。与祖先等位基因AA的纯合子相比，杂合子受试者的总体肥胖和中心性肥胖程度更高（BMI>30 kg/m²的比值比为2.35，95%置信区间为1.29 - 4.29；WHtR>0.5的比值比为2.03，95%置信区间为1.19 - 3.45；脂肪量增加（EFM）%的比值比为1.72，95%置信区间为1.01 - 2.92；脂肪量指数（FMI）>p85的比值比为1.96，95%置信区间为1.05 - 3.68）。rs1805086与代谢改变无关。