Department of Physical Education, Faculty of Individual Sports, Jozef Pilsudski University of Physical Education in Warsaw, 00-968 Warszawa, Poland.
Academic Department of Physical Education, Plekhanov Russian University of Economics, Moscow 117997, Russia.
Genes (Basel). 2022 Nov 7;13(11):2055. doi: 10.3390/genes13112055.
Polymorphism (rs1805086), , () of the myostatin gene () has been associated with a skeletal muscle phenotype (hypertrophic response in muscles due to strength training). However, there are not enough reliable data to demonstrate whether rs1805086 K and R allelic variants are valid genetic factors that can affect the strength phenotype of athletes' skeletal muscles. The aim is to conduct a systematic review and meta-analysis of the association of rs1805086 polymorphism with the strength phenotype of athletes. This study analyzed 71 research articles on and performed a meta-analysis of rs1805086 polymorphism in strength-oriented athletes and a control (non-athletes) group. It was found that athletes in the strength-oriented athlete group had a higher frequency of the minor variant than that in the control group (OR = 2.02, = 0.05). Thus, the obtained results convincingly demonstrate that there is an association between the studied polymorphism and strength phenotype of athletes; therefore, further studies on this association are scientifically warranted.
肌生成抑制素基因(rs1805086)的多态性与骨骼肌表型（由于力量训练导致肌肉肥大反应）有关。然而，没有足够可靠的数据表明 rs1805086 K 和 R 等位基因变异是否是影响运动员骨骼肌力量表型的有效遗传因素。本研究旨在对 rs1805086 多态性与运动员力量表型的相关性进行系统评价和荟萃分析。该研究分析了 71 篇关于 rs1805086 多态性的研究文章，并对力量型运动员和对照组（非运动员）的 rs1805086 多态性进行了荟萃分析。结果发现，力量型运动员组的运动员中， minor 变异型的频率高于对照组（OR = 2.02， = 0.05）。因此，所得结果令人信服地表明，所研究的多态性与运动员的力量表型之间存在关联；因此，有必要对这种关联进行进一步的研究。
