Dou L J, Zhang Q F, Bao H H, Wu W K, Sheng J, Yan S Q, Xu Y Y, Gu C L, Huang K, Cao H, Su P Y, Tao F B, Hao J H
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University/Ministry of Education Key Laboratory of Health of New-born Population, Hefei 230032, China.
Department of Child Health Care, Maternal and Child Health Care Center of Ma'anshan, Ma'anshan 243000, Anhui Province, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2020 Jun 6;54(6):644-650. doi: 10.3760/cma.j.cn112150-20190902-00696.
To explore the association between maternal bisphenol A (BPA) exposure during pregnancy and neurobehavioral development in infant. Participants were from the Ma'anshan Birth Cohort, which was established from October 2008 to October 2010 based on four municipal medical and health institutions in Ma'anshan. High-performance liquid chromatography-tandem mass spectrometry was applied for the determination of serum BPA concentration in 1 783 pregnant women sampled at their first filing, and during 2.97 to 28.1 months age of the infants. Neurobehavioral development were assessed by 0-6-year-old pediatric examination table of neuropsychological development. Generalized linear model was used to analyze the association between serum BPA levels during pregnancy and infants' neurobehavioral development. A total of 931 mother-child pairs had complete data on serum BPA detection during pregnancy and assessment of infants' neurobehavioral development status. The age of pregnant women at their first filing was (26.67±3.45) years old, and the (,) of serum BPA concentration (ng/ml) was 0.23 (0.11, 0.52), with a detection rate of 84.1% (783/931). The age of infants was (13.18±5.46) months, and 53.5% (498) were boys. The developmental quotient scores of large motor, fine motor, adaptive ability, language ability and social behaviors of infants were (97.88±16.32), (97.16±15.35), (99.64±15.47), (95.3±16.04) and (98.95±14.76) points, respectively. Generalized linear model showed that after adjusting for factors such as delivery mode, feeding mode, family per capita monthly income, preterm delivery, gender, maternal age, residence, pre-pregnancy body mass index and residence time, serum BPA level in pregnancy was negatively associated with infant's development of social behavior [β (95%):-2.42 (-4.71, -0.12)]. The post-stratification analysis by infant age revealed that the serum BPA level in pregnancy was only negatively associated with the development of language and social behavior developmental quotient scores in infants between the ages of 12 and 18 months, with β (95%) about -6.66 (-13.06, -0.25) and -7.401 (-12.97, -1.83), respectively. BPA exposure during pregnancy affects language and social behavior development in infants, and the detection window is between 12 and 18 months old of the infant.
探讨孕期母亲双酚A（BPA）暴露与婴儿神经行为发育之间的关联。研究对象来自马鞍山出生队列，该队列于2008年10月至2010年10月基于马鞍山市的四家市级医疗卫生机构建立。采用高效液相色谱-串联质谱法测定了1783名孕妇首次建档时以及婴儿2.97至28.1月龄时的血清BPA浓度。通过0-6岁儿童神经心理发育检查表评估神经行为发育情况。使用广义线性模型分析孕期血清BPA水平与婴儿神经行为发育之间的关联。共有931对母婴拥有孕期血清BPA检测及婴儿神经行为发育状况评估的完整数据。孕妇首次建档时的年龄为（26.67±3.45）岁，血清BPA浓度（ng/ml）的中位数为0.23（0.11，0.52），检出率为84.1%（783/931）。婴儿年龄为（13.18±5.46）个月，53.5%（498名）为男孩。婴儿大运动、精细运动、适应能力、语言能力和社会行为的发育商得分分别为（97.88±16.32）、（97.16±15.35）、（99.64±15.47）、（95.3±16.04）和（98.95±14.76）分。广义线性模型显示，在调整分娩方式、喂养方式、家庭人均月收入、早产、性别、母亲年龄、居住地、孕前体重指数和居住时间等因素后，孕期血清BPA水平与婴儿社会行为发育呈负相关[β（95%）：-2.42（-4.71，-0.12）]。按婴儿年龄进行的分层后分析显示，孕期血清BPA水平仅与12至18月龄婴儿的语言和社会行为发育商得分呈负相关，β（95%）分别约为-6.66（-13.06，-0.25）和-7.401（-12.97，-1.83）。孕期BPA暴露会影响婴儿的语言和社会行为发育，检测窗口期为婴儿12至18月龄。
