Chen X, Bao H H, Wu W K, Yan S Q, Sheng J, Xu Y Y, Gu C L, Huang K, Cao H, Su P Y, Tao F B, Hao J H
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China.
Ma'anshan Maternal and Child Health Center, Ma'anshan 243000, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2018 Feb 10;39(2):188-193. doi: 10.3760/cma.j.issn.0254-6450.2018.02.010.
To explore the long-term effects of maternal pregnancy bisphenol A (BPA) exposure on emotional and behavioral problems appeared in their preschool children. The study sample was a subset of the China-Anhui Birth Cohort Study (C-ABCS). A unified questionnaire was used to collect basic information on both pregnant women and their children. Free BPA concentration in maternal serum was determined by high-performance liquid chromatographytandem mass spectrometry (HPLC-MS/MS). The parent-report version of the Strengths and Difficulties Questionnaire (SDQ) was used to estimate the emotional and behavioral problems in preschool children. A total of 1 713 pairs of mothers and children were included in this study. Association between BPA exposure during pregnancy and the emotional and behavioral problems in preschool children was evaluated with multinomial logistic regression model. Prevalence rates in 1 713 preschool children appeared as: 6.48% of emotional problems, 8.11% for conduct problems, 8.35% for hyperactivity/inattention, 2.86% for peer problems, 11.38% for prosocial behaviors and 7.94% for total difficulties. Subjects were divided according to the degrees of exposure and the results showed as: low exposure group (≤0.120 ng/ml), medium exposure group (0.120<BPA<0.400 ng/ml) and high exposure group (≥0.400 ng/ml) according to the serum BPA concentration in tertile. Results from the multivariate logistic regression analysis showed that high level of maternal BPA exposure appeared a risk factor on children's abnormal conducts (=1.876, 95% : 1.161-3.029), more obvious in boys (=2.291, 95%: 1.126-4.661). Maternal exposure to high level of BPA during pregnancy might increase the detrimental effects of abnormal conducts in their preschool children, more obviously seen in boys.
为探讨孕期母亲双酚A（BPA）暴露对其学龄前儿童出现的情绪和行为问题的长期影响。研究样本是中国安徽出生队列研究（C-ABCS）的一个子集。使用统一问卷收集孕妇及其子女的基本信息。采用高效液相色谱-串联质谱法（HPLC-MS/MS）测定孕妇血清中游离BPA浓度。使用长处与困难问卷（SDQ）的家长报告版本评估学龄前儿童的情绪和行为问题。本研究共纳入1713对母婴。采用多项逻辑回归模型评估孕期BPA暴露与学龄前儿童情绪和行为问题之间的关联。1713名学龄前儿童的患病率如下：情绪问题为6.48%，品行问题为8.11%，多动/注意力不集中为8.35%，同伴问题为2.86%，亲社会行为为11.38%，总困难为7.94%。根据暴露程度将受试者分为三组，结果显示：根据血清BPA浓度三分位数，低暴露组（≤0.120 ng/ml）、中暴露组（0.120＜BPA＜0.400 ng/ml）和高暴露组（≥0.400 ng/ml）。多因素逻辑回归分析结果显示，母亲孕期高水平BPA暴露是儿童行为异常的危险因素（比值比=1.876，95%可信区间：1.161-3.029），在男孩中更明显（比值比=2.291，95%可信区间：1.126-4.661）。孕期母亲暴露于高水平BPA可能会增加其学龄前儿童行为异常的有害影响，在男孩中更明显。
