Xu Xuanwen, Ren Shuangshuang, Li Lu, Zhou Yi, Peng Wenzao, Xu Yan
Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Department of Periodontology, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China *These authors contributed equally to this article.
J Biomater Appl. 2021 Jul;36(1):55-75. doi: 10.1177/0885328220952250. Epub 2020 Aug 25.
Considering the specificity of periodontium and the unique advantages of electrospinning, this technology has been used to fabricate biodegradable tissue engineering materials for functional periodontal regeneration. For better biomedical quality, a continuous technological progress of electrospinning has been performed. Based on property of materials (natural, synthetic or composites) and additive novel methods (drug loading, surface modification, structure adjustment or 3 D technique), various novel membranes and scaffolds that could not only relief inflammation but also influence the biological behaviors of cells have been fabricated to achieve more effective periodontal regeneration. This review provides an overview of the usage of electrospinning materials in treatments of periodontitis, in order to get to know the existing research situation and find treatment breakthroughs of the periodontal diseases.
考虑到牙周组织的特殊性以及静电纺丝的独特优势,该技术已被用于制备用于功能性牙周组织再生的可生物降解组织工程材料。为了获得更好的生物医学性能,静电纺丝技术一直在持续进步。基于材料的性质(天然、合成或复合材料)以及新的添加方法(药物负载、表面改性、结构调整或3D技术),已经制备出了各种新型膜和支架,它们不仅可以减轻炎症,还能影响细胞的生物学行为,以实现更有效的牙周组织再生。这篇综述概述了静电纺丝材料在牙周炎治疗中的应用,以便了解现有研究状况并找到牙周疾病的治疗突破点。