Division of Pediatric Rheumatology, Department of Pediatrics, Duke Children's Hospital and Health Center, Durham, North Carolina, USA
Department of Pathology, Duke University Hospital, Durham, North Carolina, USA.
BMJ Case Rep. 2020 Aug 24;13(8):e234302. doi: 10.1136/bcr-2020-234302.
Kikuchi-Fujimoto disease (KFD) is a rare lymphohistiocytic disorder which can cause prolonged fever and other systemic B symptoms including diffuse lymphadenopathy. Given its clinical presentation, there is often initial concern for lymphoma and diagnosis requires lymph node biopsy. It most frequently affects young women of Asian descent; it is less commonly encountered in paediatric patients. KFD is typically a benign, self-limited process, however, there is an association with development of systemic lupus erythematosus. Given its rarity, it remains unclear if KFD is associated with other chronic conditions. Here we present the third case of KFD occurring in a paediatric patient with sickle cell disease.
菊池古氏病（KFD）是一种罕见的淋巴组织细胞疾病，可引起长期发热和其他全身 B 症状，包括弥漫性淋巴结病。鉴于其临床表现，通常最初会担心是淋巴瘤，诊断需要进行淋巴结活检。它最常影响亚洲血统的年轻女性；在儿科患者中较少见。KFD 通常是良性的、自限性的，但与系统性红斑狼疮的发展有关。由于其罕见性，目前尚不清楚 KFD 是否与其他慢性疾病有关。在这里，我们报告了第三例发生在镰状细胞病儿科患者中的 KFD 病例。
