Nastruzzi C, Feriotto G, Spandidos D, Anzanel D, Ferroni R, Guarneri M, Barbieri R, Gambari R
Dipartimento di Scienze Farmaceutiche, Universitá di Ferrara, Italy.
Anticancer Res. 1988 Mar-Apr;8(2):269-73.
Tetra benzamidine derivatives were found to inhibit proteinase activity, cell proliferation and accumulation of the Ha-ras-1 mRNA in the FHO6T1-1 Chinese Hamster cell line, transformed with the activated human T24-Ha-ras-1 oncogene. Di- and Tri-benzamidine derivatives were also found to be potent inhibitors of proliferation of FHO6T1-1 cells. These latter compounds could be proposed as useful substrates in the synthesis of drug-conjugated monoclonal antibodies or growth factors.
已发现四苯甲脒衍生物可抑制蛋白酶活性、细胞增殖以及FHO6T1-1中国仓鼠细胞系中Ha-ras-1 mRNA的积累，该细胞系由活化的人T24-Ha-ras-1癌基因转化而来。还发现二苯甲脒和三苯甲脒衍生物是FHO6T1-1细胞增殖的有效抑制剂。后一类化合物可被提议作为合成药物偶联单克隆抗体或生长因子的有用底物。
